Trial reportClinical research in cardiology : official journal of the German Cardiac Society2015
Angiopoietin-2 and outcome in patients with acute decompensated heart failure.
Trial report in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01429857 (Prognostic Relevance of High-sensitivity Troponin in Patients With Acute Decompensated Heart Failure), which is not on this map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prognostic Relevance of High-sensitivity Troponin in Patients With Acute Decompensated Heart Failure
Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Emerging biomarkers for vascular remodeling in volume and pressure overload in a cardiology cohort.International journal of cardiology. Heart & vasculature · 2025Article
- Cardiogenic Shock Integrated PHenotyping for Event Reduction: A Pilot Metabolomics Analysis.International journal of molecular sciences · 2023Article
- Impact of the elevated angiopoietin-2 levels during Impella support on the short-term prognosis.Journal of artificial organs : the official journal of the Japanese Society for Artificial Organs · 2023Article
- Plasma thrombomodulin levels are associated with acute kidney injury in patients with acute heart failure.Annals of medicine · 2022Article
- Space microgravity improves proliferation of human iPSC-derived cardiomyocytes.Stem cell reports · 2022Article
- Relationship between markers of inflammation and hemodynamic stress and death in patients with out-of-hospital cardiac arrest.Scientific reports · 2021Article
- Angiopoietin 2 as a Novel Potential Biomarker for Acute Aortic Dissection.Frontiers in cardiovascular medicine · 2021Article
- Article
- Accelerating Biomarker Discovery Through Electronic Health Records, Automated Biobanking, and Proteomics.Journal of the American College of Cardiology · 2019Article
- The Role of Cardiokines in Heart Diseases: Beneficial or Detrimental?BioMed research international · 2018Review
- FGF21 protects myocardial ischemia-reperfusion injury through reduction of miR-145-mediated autophagy.American journal of translational research · 2018Article
- Clinical effects of long-term cardiac contractility modulation (CCM) in subjects with heart failure caused by left ventricular systolic dysfunction.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Therapeutic targeting of the angiopoietin-TIE pathway.Nature reviews. Drug discovery · 2017Review
- Low circulating microRNA levels in heart failure patients are associated with atherosclerotic disease and cardiovascular-related rehospitalizations.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Role of angiopoietin-2 in the cardioprotective effect of fibroblast growth factor 21 on ischemia/reperfusion-induced injury in H9c2 cardiomyocytes.Experimental and therapeutic medicine · 2017Article
- Midregional proadrenomedullin and growth differentiation factor-15 are not influenced by obesity in heart failure patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Variants in angiopoietin-2 (ANGPT2) contribute to variation in nocturnal oxyhaemoglobin saturation level.Human molecular genetics · 2016Article
- Relevance of angiopoietin-2 and soluble P-selectin levels in patients with pulmonary arterial hypertension receiving combination therapy with oral treprostinil: a FREEDOM-C2 biomarker substudy.Pulmonary circulation · 2016Article
- Correlation between plasma angiopoietin-1, angiopoietin-2 and matrix metalloproteinase-2 in coronary heart disease.Archives of medical science : AMS · 2016Article
- Effects of vitamin A deficiency in the postnatal mouse heart: role of hepatic retinoid stores.American journal of physiology. Heart and circulatory physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAngiopoietin-2 (Ang-2) impairs endothelial integrity. The association of Ang-2 in the presence of oedema and outcome of patients with acute decompensated heart failure (ADHF) has not been investigated. METHODS AND
resultsAngiopoietin-2 was measured in 132 ADHF patients, which were included in a monocentric, prospective trial (Clinicaltrials.gov: NCT01429857). Primary endpoint was all-cause death at 6-months. 20 healthy persons served as control group (HC). In ADHF patients, mean Ang-2 concentration at admission was significantly increased compared to HC (2,111 ± 117 vs. 971 ± 46 pg/ml, p = 0.0002). Ang-2 was increased in patients with compared to those without peripheral oedema (2,294 ± 140 vs. 1,540 ± 170 pg/ml; p = 0.009) and in patients with NYHA class III or IV symptoms compared to those with NYHA class II symptoms (2,256 ± 132 vs. 1,341 ± 380 pg/ml, p = 0.023). During the 6-month follow-up, 10 patients died. In survivors, Ang-2 significantly decreased at discharge compared to admission (2,046 ± 118 vs. 1,431 ± 93 pg/ml; p < 0.0001). Non-survivors showed no difference between Ang-2 concentration at admission and discharge (3,296 ± 594 vs. 2,909 ± 536 pg/ml). Ang-2 concentrations at discharge above 2,500 pg/ml were associated with an increased risk of death compared to Ang-2 concentrations below this threshold (Hazard ratio 8.8; 95 % confidence interval; 2.48-31.16, p < 0.001).
conclusionIn ADHF patients, Ang-2 is significantly increased compared to healthy controls, shows a relationship in the presence of oedema and is a predictor of poor outcome.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.