ArticleeLife2014
Lymph node stromal cells constrain immunity via MHC class II self-antigen presentation.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
65 citing papers in PubMed, 107 citations in OpenAlex.
- Calibrating T cell responsiveness through interactions with self.Nature reviews. Immunology · 2026Review
- Fibroblast diversity within human gut-associated lymphoid tissues.The Journal of experimental medicine · 2026Article
- Guardians of immunity: the role of tumour-draining lymph node in cancer immunity.Frontiers in cell and developmental biology · 2026Review
- Rheumatoid arthritis synovial fibroblasts modulate T cell activation.JCI insight · 2025Article
- TLR ligand sensing by lymph node FRCs directs intranodal lymphocyte accumulation to promote immune responses.iScience · 2025Article
- Intrinsic Properties of the Lymph Node Render It Immunologically Susceptible to Metastasis.Cancer discovery · 2025Article
- A temporal model of tumor-immune dynamics during the metastatic progression of high-grade serous ovarian cancer.NPJ precision oncology · 2025Article
- Fibroblasts in immune responses, inflammatory diseases and therapeutic implications.Nature reviews. Rheumatology · 2025Review
- Identification and Mapping of Human Lymph Node Stromal Cell Subsets by Combining Single-Cell RNA Sequencing with Spatial Transcriptomics.European journal of immunology · 2025Article
- Review
- Senolytic treatment to rescue hallmarks of senescence in lymph node fibroblasts from patients with rheumatoid arthritis: Implications for premature aging and potential therapeutic intervention in early rheumatoid arthritis.Clinical and experimental immunology · 2025Article
- Lymph nodes as gatekeepers of autoimmune diseases.RMD open · 2024Review
- Fibril-Guided Three-Dimensional Assembly of Human Fibroblastic Reticular Cells.ACS applied bio materials · 2024Article
- Lymphatic vessels in the age of cancer immunotherapy.Nature reviews. Cancer · 2024Review
- TGF-β Signaling Prevents MHC Class II-Expressing Lymphatic Endothelial Cells from Reactivating Human Allogenic Memory CD4+ T Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023Article
- Fibroblastic reticular cells provide a supportive niche for lymph node-resident macrophages.European journal of immunology · 2023Article
- γδ T cells control murine skin inflammation and subcutaneous adipose wasting during chronic Trypanosoma brucei infection.Nature communications · 2023Article
- The aging of the immune system and its implications for transplantation.GeroScience · 2023Review
- The advent of immune stimulating CAFs in cancer.Nature reviews. Cancer · 2023Review
- New tools for immunologists: models of lymph node function from cells to tissues.Frontiers in immunology · 2023Review
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Non-hematopoietic lymph node stromal cells shape immunity by inducing MHC-I-dependent deletion of self-reactive CD8
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.