Evidence map›Paper›PMID 25407593›Full record

ArticlePediatric blood & cancer2015

Medical management of invasive fungal infections of the central nervous system in pediatric cancer patients.

John H Carter, Jennifer L Lenahan, Gisele E Ishak, J Russell Geyer, Jessica Pollard, Janet A Englund

Abstract readCase Reports
In one paragraph

Article in Pediatric blood & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 10 citations in OpenAlex.

  1. Leukemia followed by mixed infection with mucormycosis and aspergillosis: A case report and literature review.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

John H CarterDivision of Pediatric Hematology/Oncology, Seattle Children's Hospital, Seattle, Washington; Fred Hutchinson Cancer Research Center, Seattle, Washington; University of Washington, Seattle, Washington.
Jennifer L Lenahan
Gisele E Ishak
J Russell Geyer
Jessica Pollard
Janet A Englund
Seattle Children's Hospital · USFred Hutch Cancer Center · USUniversity of Washington · US

Funding

PEDIATRIC ONCOLOGY RESEARCH TRAINING PROGRAMT32CA009351 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Elizabeth R Lawlor, SOHEIL MESHINCHI · 1985 to 2026
$7.0M
NCI NIH HHS T32 CA009351NCI NIH HHS T32CA009351
6 · The paper itself

Abstract

Fungal infections of the central nervous system (CNS) are associated with high mortality rates in immunocompromised patients. Surgical intervention is a mainstay of therapy, but not always possible. We describe the use of medical therapy for the treatment of CNS fungal infections in four pediatric cancer patients. Definitive resection was not performed in any patient. All patients initially received combination antifungal therapy with good clinical response; long-term survival was documented in two patients able to transition to long-term azole therapy. Prolonged antifungal therapy is an important option for treating invasive CNS fungal infections when surgery is not feasible.

Indexed as

AdolescentAdultAntifungal AgentsCentral Nervous System InfectionsChildFemaleHumansMaleMycosesNeoplasmsAntifungal Agentsaspergilluscancercentral nervous systempediatric fungal infectionrhizopus

Identifiers

PMID25407593
PMCPMC4405402
OpenAlexW2133785595

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.