Evidence map›Paper›PMID 25407434›Full record

ReviewThe Journal of investigative dermatology2015

The role of human dendritic cells in HIV-1 infection.

Zahra Ahmed, Tatsuyoshi Kawamura, Shinji Shimada, Vincent Piguet

Open access · bronzeAbstract readReview
PubMed Publisher
In one paragraph

Review in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
3.0field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 54 citations in OpenAlex.

  1. Article
  2. Antigen Presenting Cell-Mediated HIV-1Medical research archives · 2023
    Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. The Role of Dendritic Cells in TB and HIV Infection.Journal of clinical medicine · 2020
    Review
  8. Review
  9. Article
  10. Dendritic Cell Maturation Regulates TSPAN7 Function in HIV-1 Transfer to CD4Frontiers in cellular and infection microbiology · 2020
    Article
  11. Review
  12. Article
  13. Article
  14. Lentiviral Vector-Based Dendritic Cell Vaccine Suppresses HIV Replication in Humanized Mice.Molecular therapy : the journal of the American Society of Gene Therapy · 2019
    Article
  15. CD4AIDS research and human retroviruses · 2018
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Zahra AhmedDepartment of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK.
Tatsuyoshi KawamuraFaculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
Shinji ShimadaFaculty of Medicine, Department of Dermatology, University of Yamanashi, Yamanashi, Japan.
Vincent PiguetDepartment of Dermatology, Institute of Infection and Immunity, School of Medicine, Cardiff University, University Hospital of Wales, Glamorgan House, Heath Park, Cardiff, UK. Electronic address: piguetv@cardiff.ac.uk.
University of Yamanashi · JPCardiff University · GB

Funding

Wellcome Trust 506398
6 · The paper itself

Abstract

Dendritic cells (DCs) and their subsets have multifaceted roles in the early stages of HIV-1 transmission and infection. DC studies have led to remarkable discoveries, including identification of restriction factors, cellular structures promoting viral transmission including the infectious synapse or the interplay of the C-type lectins, Langerin on Langerhans cells (LCs), and dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin on other DC subsets, limiting or facilitating HIV transmission to CD4(+) T cells, respectively. LCs/DCs are also exposed to encountering HIV-1 and other sexually transmitted infections (herpes simplex virus-2, bacteria, fungi), which reprogram HIV-1 interaction with these cells. This review will summarize advances in the role of DCs during HIV-1 infection and discuss their potential involvement in the development of preventive strategies against HIV-1 and other sexually transmitted infections.

Indexed as

HIV-1Cell CommunicationDendritic CellsHIV InfectionsHumansLangerhans CellsViral VaccinesViral Vaccines

Identifiers

PMID25407434
OpenAlexW2017804645

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.