ArticleGenes, chromosomes & cancer2015
Heterogeneous DNA methylation contributes to tumorigenesis through inducing the loss of coexpression connectivity in colorectal cancer.
Article in Genes, chromosomes & cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 19 citations in OpenAlex.
- Reliable investigation of DNA methylation using Oxford nanopore technologies.Scientific reports · 2025Article
- Deep5mC: Predicting 5-methylcytosine (5mC) methylation status using a deep learning transformer approach.Computational and structural biotechnology journal · 2025Article
- Promoter Hypomethylation Upregulates ANXA2 Expression in Pancreatic Cancer and is Associated with Poor Prognosis.Biochemical genetics · 2024Article
- Genome-Wide Correlation of DNA Methylation and Gene Expression in Postmortem Brain Tissues of Opioid Use Disorder Patients.The international journal of neuropsychopharmacology · 2021Article
- Efficient weighted univariate clustering maps outstanding dysregulated genomic zones in human cancers.Bioinformatics (Oxford, England) · 2020Article
- Lower connectivity of tumor coexpression networks is not specific to cancer.In silico biology · 2019Article
- Methylation Status of Transcriptional Modulatory Genes Associated with Colorectal Cancer in Northeast China.Gut and liver · 2018Article
- Towards integrated oncogenic marker recognition through mutual information-based statistically significant feature extraction: an association rule mining based study on cancer expression and methylation profiles.Quantitative biology (Beijing, China) · 2017Article
- Genome-wide DNA methylation analysis reveals molecular subtypes of pancreatic cancer.Oncotarget · 2017Article
- Heterogeneous pattern of DNA methylation in developmentally important genes correlates with its chromatin conformation.BMC molecular biology · 2017Article
- Transcriptome- and proteome-oriented identification of dysregulated eIF4G, STAT3, and Hippo pathways altered by PIK3CABreast cancer research and treatment · 2016Article
- Integration of genome scale data for identifying new players in colorectal cancer.World journal of gastroenterology · 2016Review
- DREAMing: a simple and ultrasensitive method for assessing intratumor epigenetic heterogeneity directly from liquid biopsies.Nucleic acids research · 2015Article
- Colorectal cancer DNA methylation patterns from patients in Manaus, Brazil.Biological research · 2015Article
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Authors and funding
4 authors at 2 institutions in 1 country.
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Abstract
Increasing evidence indicates the high heterogeneity of cancer cells. Recent studies have revealed distinct subtypes of DNA methylation in colorectal cancer (CRC); however, the mechanism of heterogeneous methylation remains poorly understood. Gene expression is a natural, intermediate quantitative trait that bridges genotypic and phenotypic features. In this work, we studied the role of heterogeneous DNA methylation in tumorigenesis via gene expression analyses. Specifically, we integrated methylation and expression data in normal and tumor tissues, and examined the perturbations in coexpression patterns. We found that the heterogeneity of methylation leads to significant loss of coexpression connectivity in CRC; this finding was validated in an independent cohort. Functional analyses showed that the lost coexpression partners participate in important cancer-related pathways/networks, such as ErbB and mitogen-activated protein kinase (MAPK) signaling pathways. Our analyses suggest that the loss of coexpression connectivity induced by methylation heterogeneity might play an important role in CRC. To our knowledge, this is the first study to interpret methylation heterogeneity in cancer from the perspective of coexpression perturbation. Our results provide new perspectives in tumor biology and may facilitate the identification of potential biomedical therapies for cancer treatment.
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