ReviewCritical care (London, England)2014
Central venous oxygenation: when physiology explains apparent discrepancies.
Review in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Variation in central venous oxygen saturation to evaluate fluid responsiveness: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Impact of hemodynamic goal-directed resuscitation on mortality in adult critically ill patients: a systematic review and meta-analysis.Journal of clinical monitoring and computing · 2018Pooled it
- Do ScvOPhysiological reports · 2021Trial
- Accuracy and precision of ScvO2 measured with the CeVOX-device: A prospective study in patients with a wide variation of ScvO2-values.PloS one · 2018Trial
- Acute Thermal Elevation Alters Cellular Metabolic Activity, Redox Balance, and Iron Homeostasis in Butterfly Lizards (Animals : an open access journal from MDPI · 2026Article
- Physiology, monitoring, and optimisation of perioperative tissue oxygenation: a narrative review.British journal of anaesthesia · 2026Review
- Preoperative and intraoperative oxygen consumption in patients undergoing lung resection surgery: a retrospective study using cardiopulmonary exercise test and intraoperative data.BMC anesthesiology · 2026Article
- Fluid management methods for severely burned patients: a narrative review.Journal of clinical monitoring and computing · 2026Review
- Evaluation of alternative transfusion triggers in hemodynamically stable, non-ventilated cancer patients: a prospective observational study.Scientific reports · 2025Observational
- Central venous oxygen saturation changes as a reliable predictor of the change of CI in septic shock: To explore potential influencing factors.Chinese journal of traumatology = Zhonghua chuang shang za zhi · 2025Article
- Variations in central venous oxygen saturation and central venous-to-arterial carbon dioxide tension difference to define fluid responsiveness: a prospective observational study.Frontiers in cardiovascular medicine · 2025Article
- Validation of the inadequate delivery of oxygen index in an adult cardiovascular intensive care unit.JTCVS open · 2024Article
- Changes in central venous-to-arterial PCOCritical care (London, England) · 2024Article
- Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations.Journal of clinical medicine · 2024Review
- Alternative blood transfusion triggers: a narrative review.BMC anesthesiology · 2024Review
- Noninvasive tracking of mixed venous oxygen saturation via near-infrared spectroscopy cerebral oximetry: a retrospective observational study.Scientific reports · 2023Observational
- Use of COJournal of cardiovascular development and disease · 2023Review
- Blood gas analysis as a surrogate for microhemodynamic monitoring in sepsis.World journal of emergency medicine · 2023Review
- Central venous-to-arterial PCOScientific reports · 2021Article
- Cardiac output estimation based on arterial and venous blood gas analysis: proposal of a monitoring method.Anaesthesiology intensive therapy · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Central venous oxygen saturation (ScvO2) >70% or mixed venous oxygen saturation (SvO2) >65% is recommended for both septic and non-septic patients. Although it is the task of experts to suggest clear and simple guidelines, there is a risk of reducing critical care to these simple recommendations. This article reviews the basic physiological and pathological features as well as the metrological issues that provide clear evidence that SvO2 and ScvO2 are adaptative variables with large inter-patient variability. This variability is exemplified in a modeled population of 1,000 standard ICU patients and in a real population of 100 patients including 15,860 measurements. In these populations, it can be seen how optimizing one to three of the four S(c)vO2 components homogenized the patients and yields a clear dependency with the fourth one. This explains the discordant results observed in large studies where cardiac output was increased up to predetermined S(c)vO2 thresholds following arterial oxygen hemoglobin saturation, total body oxygen consumption needs and hemoglobin optimization. Although a systematic S(c)vO2 goal-oriented protocol can be statistically profitable before ICU admission, appropriate intensive care mandates determination of the best compromise between S(c)vO2 and its four components, taking into account the specific constraints of each individual patient.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.