ArticleLab on a chip2015
Towards microfluidic-based depletion of stiff and fragile human red cells that accumulate during blood storage.
Article in Lab on a chip, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Fundamentals of big data and artificial intelligence in transfusion medicine.Vox sanguinis · 2026Review
- Microfluidic Chip Platforms for Red Blood Cell Storage Lesion Quality Control and Precision Transfusion.Research (Washington, D.C.) · 2026Review
- New and emerging technologies for pretransfusion blood quality assessment: A state-of-the-art review.Transfusion · 2024Review
- Biomechanical Investigation of Red Cell Sedimentation Using Blood Shear Stress and Blood Flow Image in a Capillary Chip.Micromachines · 2023Article
- Assessment of stored red blood cells through lab-on-a-chip technologies for precision transfusion medicine.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Advances in Microfluidics for Single Red Blood Cell Analysis.Biosensors · 2023Review
- Amine-modified nanoplastics promote the procoagulant activation of isolated human red blood cells and thrombus formation in rats.Particle and fibre toxicology · 2022Article
- Development of a flow standard to enable highly reproducible measurements of deformability of stored red blood cells in a microfluidic device.Transfusion · 2020Article
- Stiffness and ATP recovery of stored red blood cells in serum.Microsystems & nanoengineering · 2019Article
- Optofluidic laser speckle image decorrelation analysis for the assessment of red blood cell storage.PloS one · 2019Article
- Enhanced separation of aged RBCs by designing channel cross section.Biomicrofluidics · 2018Article
- Determination of red blood cell deformability using centrifugal force in a three-dimensional-printed mini-disk (3D-PMD).PloS one · 2018Article
- Study of individual erythrocyte deformability susceptibility to INFeD and ethanol using a microfluidic chip.Scientific reports · 2016Article
- Quantifying morphological heterogeneity: a study of more than 1 000 000 individual stored red blood cells.Vox sanguinis · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In this study, the effects of prolonged storage on several biophysical properties of red blood cells (RBCs) were investigated. Single cell deformability was used as an important criterion in determining subgroups of RBCs evolved during storage lesion. A deformability-based microfluidic cell sorting technology was applied, which demonstrates the ability to enrich and separate the less deformable subpopulations of stored blood. These less deformable RBC subpopulations were then associated with other important markers such as osmotic fragility indicating cell integrity as well as microparticle content. This work demonstrates a systematic methodology to both monitor and improve banked blood quality, thereby reducing risks related to blood transfusion.
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