Trial reportAlcoholism, clinical and experimental research2014
Increased forebrain activations in youths with family histories of alcohol and other substance use disorders performing a Go/NoGo task.
Trial report in Alcoholism, clinical and experimental research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 26 citations in OpenAlex.
- Meta-analysis and review of functional neuroimaging differences underlying adolescent vulnerability to substance use.NeuroImage · 2020Pooled it
- Sex-specific differences in brain activity dynamics of youth with a family history of substance use disorder.Nature. Mental health · 2025Article
- The Genetically Informed Neurobiology of Addiction (GINA) model.Nature reviews. Neuroscience · 2023Review
- Behavioral and brain signatures of substance use vulnerability in childhood.Developmental cognitive neuroscience · 2020Article
- The Development of Impulsivity and Sensation Seeking: Associations with Substance Use among At-Risk Adolescents.Journal of research on adolescence : the official journal of the Society for Research on Adolescence · 2020Article
- Parental Family History of Alcohol Use Disorder and Neural Correlates of Response Inhibition in Children From the Adolescent Brain Cognitive Development (ABCD) Study.Alcoholism, clinical and experimental research · 2020Article
- The disengaging brain: Dynamic transitions from cognitive engagement and alcoholism risk.NeuroImage · 2020Article
- The effect of alcohol use on neuroimaging correlates of cognitive and emotional processing in human adolescence.Neuropsychology · 2019Review
- Differentiating the Effects of Familial Risk for Alcohol Dependence and Prenatal Exposure to Alcohol on Offspring Brain Morphology.Alcoholism, clinical and experimental research · 2017Article
- Adolescence and Drug Use Vulnerability: Findings from Neuroimaging.Current opinion in behavioral sciences · 2017Article
- The adolescent brain at risk for substance use disorders: a review of functional MRI research on motor response inhibition.Current opinion in behavioral sciences · 2017Article
- Verbal Learning and Memory in Cannabis and Alcohol Users: An Event-Related Potential Investigation.Frontiers in psychology · 2017Article
- Association of Drinking Problems and Duration of Alcohol Use to Inhibitory Control in Nondependent Young Adult Social Drinkers.Alcoholism, clinical and experimental research · 2016Article
- Neurobiological phenotypes associated with a family history of alcoholism.Drug and alcohol dependence · 2016Review
- Striatal activity and reduced white matter increase frontal activity in youths with family histories of alcohol and other substance-use disorders performing a go/no-go task.Brain and behavior · 2015Article
- Conflict anticipation in alcohol dependence - A model-based fMRI study of stop signal task.NeuroImage. Clinical · 2015Article
- Neurophysiological Correlates and Differential Drug Response in Subjects With a Family History of an Alcohol Use Disorder.Chronic stress (Thousand Oaks, Calif.)Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundYouths with a family history of alcohol and other drug use disorders (FH+) are at a greater risk of developing substance use disorders than their peers with no such family histories (FH-), and this increased risk may be related to impaired maturation of forebrain circuitry. FH+ individuals have shown altered forebrain activity at rest and while performing cognitive tasks. However, it is not fully understood how forebrain activity is altered in FH+ individuals, and ultimately how these alterations may contribute to substance use disorder risk.
methodsIn this study, we tested 72 FH+ and 32 FH- youths performing a go/no-go task and examined activations in blocks with only go trials (Go Only), blocks with 50% go and 50% no-go trials (Go/NoGo), and a contrast of those 2 blocks.
resultsFH+ youths had significantly greater cerebral activations in both the Go and Go/NoGo blocks than FH- youths in regions including the posterior cingulate/precuneus, bilateral middle/superior temporal gyrus, and medial superior frontal gyrus with no significant group differences in the subtraction between Go Only and Go/NoGo blocks. Additionally, FH+ youths had moderately slower reaction times on go trials in the Go Only blocks.
conclusionsOur findings suggest that global activation increase in FH+ youths are modulated by FH density and are not specific to the inhibitory components of the task. This pattern of increased activations in FH+ youths may be at least partially due to impaired forebrain white matter development leading to greater activations/less efficient neural communication during task performance.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.