Evidence map›Paper›PMID 25406515›Full record

ArticleNature communications2014

Long noncoding RNA PANDA and scaffold-attachment-factor SAFA control senescence entry and exit.

Pavan Kumar Puvvula, Rohini Devi Desetty, Pascal Pineau, Agnés Marchio, Anne Moon, Anne Dejean, Oliver Bischof

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
124citing papers in PubMed, 2 pooled it
6.4field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

124 citing papers in PubMed, 2 syntheses or guidelines pooled it, 198 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Review
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    Article
  12. Review
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  15. Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article

64 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Pavan Kumar Puvvula1] Department of Pediatrics, University of Utah, Salt Lake City, Utah 84102, USA [2] Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA.
Rohini Devi DesettyWeis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA.
Pascal Pineau1] Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, F-75015 Paris, France [2] INSERM, U993, F-75015 Paris, France [3] Equipe Labellisée Ligue Nationale Contre le Cancer, F-75015 Paris, France.
Agnés Marchio1] Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, F-75015 Paris, France [2] INSERM, U993, F-75015 Paris, France [3] Equipe Labellisée Ligue Nationale Contre le Cancer, F-75015 Paris, France.
Anne Moon1] Department of Pediatrics, University of Utah, Salt Lake City, Utah 84102, USA [2] Weis Center for Research, Geisinger Clinic, Danville, Pennsylvania 17822, USA.
Anne Dejean1] Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, F-75015 Paris, France [2] INSERM, U993, F-75015 Paris, France [3] Equipe Labellisée Ligue Nationale Contre le Cancer, F-75015 Paris, France.
Oliver Bischof1] Institut Pasteur, Laboratory of Nuclear Organization and Oncogenesis, F-75015 Paris, France [2] INSERM, U993, F-75015 Paris, France.
Institut Pasteur · FRGeisinger Medical Center · USOrganisation Nucléaire et OncogenèseUniversity of Utah · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous cells. Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding RNA PANDA differentially interact with polycomb repressive complexes (PRC1 and PRC2) and the transcription factor NF-YA to either promote or suppress senescence. In proliferating cells, SAFA and PANDA recruit PRC complexes to repress the transcription of senescence-promoting genes. Conversely, the loss of SAFA-PANDA-PRC interactions allows expression of the senescence programme. Accordingly, we find that depleting either SAFA or PANDA in proliferating cells induces senescence. However, in senescent cells where PANDA sequesters transcription factor NF-YA and limits the expression of NF-YA-E2F-coregulated proliferation-promoting genes, PANDA depletion leads to an exit from senescence. Together, our results demonstrate that PANDA confines cells to their existing proliferative state and that modulating its level of expression can cause entry or exit from senescence.

Indexed as

CCAAT-Binding FactorCell Cycle CheckpointsCell Cycle ProteinsCell LineCellular SenescenceE2F Transcription FactorsFibroblastsHeterogeneous-Nuclear Ribonucleoprotein UHumansPolycomb Repressive Complex 2RNA, Long NoncodingCCAAT-Binding FactorCell Cycle ProteinsE2F Transcription FactorsHeterogeneous-Nuclear Ribonucleoprotein UNFYA protein, humanPolycomb Repressive Complex 2PRC1 protein, humanRNA, Long Noncoding

Identifiers

PMID25406515
PMCPMC4263151
OpenAlexW2084308291

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.