ArticleBMC cancer2014
Surgical resection of nodular ground-glass opacities without percutaneous needle aspiration or biopsy.
Article in BMC cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 48 citations in OpenAlex.
- Percutaneous Transthoracic Needle Biopsy May Increase Recurrence in Early-Stage Non-Small Cell Lung Cancer: A Propensity Score-Matched Analysis.Annals of surgical oncology · 2026Article
- Article
- Screening for Lung Cancer, Overdiagnosis, and Healthcare Utilization: A Nationwide Population-Based Study.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2025Article
- Exploring the risk factors for the growth of pure ground-glass nodules in a 3-year follow-up period.Quantitative imaging in medicine and surgery · 2025Article
- Article
- Differential diagnosis of pulmonary nodules and prediction of invasive adenocarcinoma using extracellular vesicle DNA.Clinical and translational medicine · 2024Article
- Thin-slice computed tomography enables to classify pulmonary subsolid nodules into pre-invasive lesion/minimally invasive adenocarcinoma and invasive adenocarcinoma: a retrospective study.Scientific reports · 2023Article
- A triple-classification for the evaluation of lung nodules manifesting as pure ground-glass sign: a CT-based radiomic analysis.BMC medical imaging · 2022Article
- Surgery without preoperative histological confirmation of lung cancer: what is the current clinical practice?Journal of thoracic disease · 2021Article
- Deep learning-based differentiation of invasive adenocarcinomas from preinvasive or minimally invasive lesions among pulmonary subsolid nodules.European radiology · 2021Article
- Predicting malignancy: subsolid nodules detected on LDCT in a surgical cohort of East Asian patients.Journal of thoracic disease · 2020Article
- The combined nomogram based on the CT features may be used as a complementary method of frozen sections to predict invasive lung adenocarcinoma manifesting as ground-glass nodules.Journal of thoracic disease · 2020Article
- Contrast analysis of the relationship between the HRCT sign and new pathologic classification in small ground glass nodule-like lung adenocarcinoma.La Radiologia medica · 2019Article
- Atypical pulmonary alveolar proteinosis presenting as a mixed nodular ground-glass opacity with focal mucinosis mimicking lung cancer.Journal of thoracic disease · 2018Article
- High-resolution computed tomography features and CT-guided microcoil localization of subcentimeter pulmonary ground-glass opacities: radiological processing prior to video-assisted thoracoscopic surgery.Journal of thoracic disease · 2018Article
- Ground glass opacities management in the lung cancer screening era.Annals of translational medicine · 2018Review
- Advances in intelligent diagnosis methods for pulmonary ground-glass opacity nodules.Biomedical engineering online · 2018Review
- Software-based risk stratification of pulmonary adenocarcinomas manifesting as pure ground glass nodules on computed tomography.European radiology · 2018Article
- CT assessment-based direct surgical resection of part-solid nodules with solid component larger than 5 mm without preoperative biopsy: experience at a single tertiary hospital.European radiology · 2017Article
- Preoperative nomogram for identifying invasive pulmonary adenocarcinoma in patients with pure ground-glass nodule: A multi-institutional study.Oncotarget · 2017Article
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPercutaneous needle aspiration or biopsy (PCNA or PCNB) is an established diagnostic technique that has a high diagnostic yield. However, its role in the diagnosis of nodular ground-glass opacities (nGGOs) is controversial, and the necessity of preoperative histologic confirmation by PCNA or PCNB in nGGOs has not been well addressed.
methodsWe here evaluated the rates of malignancy and surgery-related complications, and the cost benefits of resecting nGGOs without prior tissue diagnosis when those nGGOs were highly suspected for malignancy based on their size, radiologic characteristics, and clinical courses. Patients who underwent surgical resection of nGGOs without preoperative tissue diagnosis from January 2009 to October 2013 were retrospectively analyzed.
resultsAmong 356 nGGOs of 324 patients, 330 (92.7%) nGGOs were resected without prior histologic confirmation. The rate of malignancy was 95.2% (314/330). In the multivariate analysis, larger size was found to be an independent predictor of malignancy (odds ratio, 1.086; 95% confidence interval, 1.001-1.178, p =0.047). A total of 324 (98.2%) nGGOs were resected by video-assisted thoracoscopic surgery (VATS), and the rate of surgery-related complications was 6.7% (22/330). All 16 nGGOs diagnosed as benign nodules were resected by VATS, and only one patient experienced postoperative complications (prolonged air leak). Direct surgical resection without tissue diagnosis significantly reduced the total costs, hospital stay, and waiting time to surgery.
conclusionsWith careful selection of nGGOs that are highly suspicious for malignancy, surgical resection of nGGOs without tissue diagnosis is recommended as it reduces costs and hospital stay.
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