ArticleGastroenterology report2015
Diagnostic efficacy of whole-body diffusion-weighted imaging in the detection of tumour recurrence and metastasis by comparison with 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography or computed tomography in patients with gastrointestinal cancer.
Article in Gastroenterology report, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 22 citations in OpenAlex.
- Review
- Diagnostic Value of Magnetic Resonance Diffusion-Weighted Imaging Combined with Routine Scanning in Body Tumors.Contrast media & molecular imaging · 2022Article
- Optimal Modality for Detecting Distant Metastasis in Primary Nasopharyngeal Carcinoma during Initial Staging: A Systemic Review and Meta-analysis of 1774 Patients.Journal of Cancer · 2017Article
- Advanced imaging of colorectal cancer: From anatomy to molecular imaging.Insights into imaging · 2016Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe primary aim of this study was to assess the efficacy of whole-body diffusion-weighted imaging (WB-DWI) in detecting tumour recurrence and metastasis of gastrointestinal cancers by comparison with 18F-2-fluoro-2-deoxy-D-glucose positron emission tomography or computed tomography ((18)F-FDG-PET/CT). A secondary aim was to evaluate the change of apparent diffusion coefficient (ADC) value between metastases and normal tissues.
methodsTwenty-eight previously confirmed gastrointestinal cancer patients with suspected tumour recurrence or metastasis were recruited. WB-DWI and PET/CT images were evaluated by two radiologists and a nuclear medicine physician. Agreement between WB-DWI and PET/CT for detective efficacy was compared using kappa statistics. Additionally, diagnostic accuracy, sensitivity, specificity, negative predictive value (NPV), and positive predictive value (PPV) were also statistically analysed. ADC values between metastatic and normal tissues were compared.
resultsThere was no statistically significant difference (P > 0.05) in the overall diagnostic performances of PET/CT (accuracy 98.9%; sensitivity 95.2%; specificity 99.8%; PPV 98.9%; NPV 98.9%) and WB-DWI (accuracy 95.9%; sensitivity 81.7%; specificity 99.1%; PPV 95.0%; NPV 96.1%). WB-DWI showed agreement with PET/CT (κ = 0.877) for detecting recurrence and distant metastases. A statistically significant difference in ADC value was observed between tissues of normal healthy volunteers and metastases in lymph nodes, liver and bones (P < 0.05).
conclusionsWB-DWI is reliable in detecting tumour recurrence and metastasis of colorectal cancer and offers the same diagnostic performance as (18)F-PET/CT without ionizing radiation. The quantitative value of ADC provides extra information to determine cancer metastasis.
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