Evidence map›Paper›PMID 25406224›Full record

ReviewThe Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry2016

Cerebellar Transcranial Direct Current Stimulation (ctDCS): A Novel Approach to Understanding Cerebellar Function in Health and Disease.

Giuliana Grimaldi, Georgios P Argyropoulos, Amy Bastian, Mar Cortes, Nicholas J Davis, Dylan J Edwards, Roberta Ferrucci, Felipe Fregni, Joseph M Galea, Masahi Hamada and 8 more

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 130 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
130citing papers in PubMed, 7 pooled it
10.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

130 citing papers in PubMed, 7 syntheses or guidelines pooled it, 235 citations in OpenAlex.

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  17. Cerebellar Transcranial Direct Current Stimulation in Spinocerebellar Ataxia Type 3: a Randomized, Double-Blind, Sham-Controlled Trial.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022
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70 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 13 institutions in 4 countries.

Giuliana GrimaldiUnité d'Etude du Mouvement, ULB-Erasme, Brussels, Belgium.
Georgios P ArgyropoulosDepartment of Psychology, Brain, Action and Cognition Lab, University of London, Egham, Surrey, UK.
Amy BastianDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Mar CortesBurke Medical Research Institute, Departments of Neurology and Neuroscience, Weill Medical College of Cornell University, White Plains, NY, USA.
Nicholas J DavisDepartment of Psychology, Swansea University, Swansea, UK.
Dylan J EdwardsBurke Medical Research Institute, Departments of Neurology and Neuroscience, Weill Medical College of Cornell University, White Plains, NY, USA.
Roberta FerrucciDepartment of Medical-Surgical Pathophysiology and Transplants, University of Milan, Milan, Italy Clinical Center for Neurotechnology, Neurostimulation and Movement Disorders, Fondazione IRCCS "Ca' Granda" Ospedale Maggiore di Milano, Milan, Italy.
Felipe FregniCenter of Neuromodulation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Joseph M GaleaSchool of Psychology, University of Birmingham, Edgbaston, Birmingham, UK.
Masahi HamadaDepartment of Neurology, The University of Tokyo, Tokyo, Japan.
Mario MantoUnité d'Etude du Mouvement, ULB-Erasme, Brussels, Belgium.
R Chris MiallSchool of Psychology, University of Birmingham, Edgbaston, Birmingham, UK.
Leon Morales-QuezadaCenter of Neuromodulation, Spaulding Rehabilitation Hospital and Massachusetts General Hospital, Harvard University, Boston, MA, USA.
Paul A PopeSchool of Psychology, University of Birmingham, Edgbaston, Birmingham, UK.
Alberto PrioriDepartment of Medical-Surgical Pathophysiology and Transplants, University of Milan, Milan, Italy Clinical Center for Neurotechnology, Neurostimulation and Movement Disorders, Fondazione IRCCS "Ca' Granda" Ospedale Maggiore di Milano, Milan, Italy.
John RothwellInstitute of Neurology, University College London, London, UK.
S Paul TomlinsonSchool of Psychology, Bangor University, Bangor, UK.
Pablo CelnikDepartment of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA Department of Physical Medicine and Rehabilitation, Johns Hopkins University School of Medicine, Baltimore, MD, USA pcelnik@jhmi.edu.
University of Birmingham · GBJohns Hopkins University · USBangor University · GBBurke Medical Research Institute · USCornell University · USFondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico · ITHarvard University · USSpaulding Rehabilitation Hospital · USSwansea University · GBThe University of Tokyo · JPUniversity College London · GBUniversity of London · GBUniversity of Milan · IT

Funding

Novel Strategies to Enhance Motor Function After StrokeR01HD053793 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CELNIK, PABLO ARIEL · 2007 to 2019
$5.2M
Transcranial Direct Current Stimulation and Robotic Training in Chronic StrokeR01HD069776 · NICHD · WINIFRED MASTERSON BURKE MED RES INST · PI EDWARDS, DYLAN JAMES · 2012 to 2016
$3.2M
Understanding Motor Behavior After StrokeR01HD073147 · NICHD · JOHNS HOPKINS UNIVERSITY · PI CELNIK, PABLO ARIEL · 2012 to 2016
$1.7M
Medical Research Council MR/K00414X/1NICHD NIH HHS 1R01HD053793NICHD NIH HHS R01 HD053793NICHD NIH HHS R01 HD069776NICHD NIH HHS R01HD069776NICHD NIH HHS R01 HD073147NICHD NIH HHS R01HD073147Wellcome Trust WT087554
6 · The paper itself

Abstract

The cerebellum is critical for both motor and cognitive control. Dysfunction of the cerebellum is a component of multiple neurological disorders. In recent years, interventions have been developed that aim to excite or inhibit the activity and function of the human cerebellum. Transcranial direct current stimulation of the cerebellum (ctDCS) promises to be a powerful tool for the modulation of cerebellar excitability. This technique has gained popularity in recent years as it can be used to investigate human cerebellar function, is easily delivered, is well tolerated, and has not shown serious adverse effects. Importantly, the ability of ctDCS to modify behavior makes it an interesting approach with a potential therapeutic role for neurological patients. Through both electrical and non-electrical effects (vascular, metabolic) ctDCS is thought to modify the activity of the cerebellum and alter the output from cerebellar nuclei. Physiological studies have shown a polarity-specific effect on the modulation of cerebellar-motor cortex connectivity, likely via cerebellar-thalamocortical pathways. Modeling studies that have assessed commonly used electrode montages have shown that the ctDCS-generated electric field reaches the human cerebellum with little diffusion to neighboring structures. The posterior and inferior parts of the cerebellum (i.e., lobules VI-VIII) seem particularly susceptible to modulation by ctDCS. Numerous studies have shown to date that ctDCS can modulate motor learning, and affect cognitive and emotional processes. Importantly, this intervention has a good safety profile; similar to when applied over cerebral areas. Thus, investigations have begun exploring ctDCS as a viable intervention for patients with neurological conditions.

Indexed as

AnimalsCerebellar AtaxiaCerebellumHumansMotor CortexNeuronal PlasticityTranscranial Direct Current StimulationcerebellumcognitivectDCSdirect current stimulationemotionlanguagelearningmodelingmotorplasticitysafetytranscranialworking memory

Identifiers

PMID25406224
PMCPMC4712385
OpenAlexW2105145689

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.