Evidence map›Paper›PMID 25406080›Full record

ArticlePloS one2014

Multicenter epidemiological study to assess the population of CKD patients in Greece: results from the PRESTAR study.

Konstantinos Sombolos, Demitrios Tsakiris, John Boletis, Demetrios Vlahakos, Kostas C Siamopoulos, Vassilios Vargemezis, Pavlos Nikolaidis, Christos Iatrou, Eugene Dafnis, Konstantinos Xynos and 1 more

Abstract readMulticenter Study
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. The National Organ Donation and Transplantation Program in Greece: Gap Analysis and Recommendations for Change.Transplant international : official journal of the European Society for Organ Transplantation · 2023
    Review
  3. Impact of Adverse Drug Reactions in Patients with End Stage Renal Disease in Greece.International journal of environmental research and public health · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Konstantinos SombolosNephrology Clinic, Papanikolaou Hospital, Thessaloniki, Greece.
Demitrios TsakirisNephrology Clinic, Papageorgiou Hospital, Thessaloniki, Greece.
John BoletisNephrology Clinic, Laiko Hospital, Athens, Greece.
Demetrios VlahakosNephrology Clinic, ATTIKON University Hospital, Athens, Greece.
Kostas C SiamopoulosNephrology Clinic, Ioannina University Hospital, Ioannina, Greece.
Vassilios VargemezisNephrology Clinic, Alexandroupoli University Hospital, Alexandroupoli, Greece.
Pavlos NikolaidisNephrology Clinic, AHEPA Hospital, Thessaloniki, Greece.
Christos IatrouCenter for Nephrology, G Papadakis, Nikea Hospital, Athens, Greece.
Eugene DafnisNephrology Clinic, PE.PA.G.N.I, Crete University Hospital, Iraklio, Greece.
Konstantinos XynosAbbVie Pharmaceuticals, Chicago, Illinois, United States of America.
Christos ArgyropoulosAbbVie Pharmaceuticals SA, Athens, Greece.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic Kidney Disease (CKD) is a relatively common condition not only associated with increased morbidity and mortality but also fuelling End Stage Renal Disease (ESRD). Among developed nations, Greece has one of the highest ESRD incidence rates, yet there is limited understanding of the epidemiology of earlier stages of CKD.

methodsCross-sectional survey of pre-dialysis CKD outpatients in nephrology clinics in the National Health Care system between October 2009 and October 2010. Demographics, cause of CKD, blood pressure, level of renal function, duration of CKD and nephrology care, and specialty of referral physician were collected and analyzed. Different methods for estimating renal function (Cockroft-Gault [CG], CKD-Epi and MDRD) and staging CKD were assessed for agreement.

resultsA total of 1,501 patients in 9 centers were enrolled. Diabetic nephropathy was the most common nephrologist assigned cause of CKD (29.7%). In total, 36.5% of patients had self-referred to the nephrologist; patients with diabetes or serum creatinine above 220 µmol/l (eGFR<40 ml/min/1.73 m2) were more likely to have been referred by a physician. Agreement between MDRD and CKD-Epi, but not between CG, the other estimating equations, was excellent. There was substantial heterogeneity with respect to renal diagnoses, referral patterns and blood pressure among participating centers.

conclusionsIn this first epidemiologic assessment of CKD in Greece, we documented delayed referral and high rates of self-referral among patients with CKD. eGFR reporting, currently offered by a limited number of laboratories, may facilitate detection of CKD at an earlier, more treatable stage.

Indexed as

AdultAgedBlood PressureCreatinineCross-Sectional StudiesDiabetic NephropathiesFemaleGreeceHumansKidneyMaleMiddle AgedReferral and ConsultationRenal Insufficiency, ChronicStatistics, NonparametricTime FactorsCreatinine

Identifiers

PMID25406080
PMCPMC4236082

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.