ArticleJournal of the American Chemical Society2014
Hydrolyzable polyureas bearing hindered urea bonds.
Article in Journal of the American Chemical Society, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 191 citations in OpenAlex.
- Topology-Regulated Polyurea: From Structural Design to Emerging Applications.Advanced materials (Deerfield Beach, Fla.) · 2026Review
- Dynamic decrosslinking enables self-healing, reprocessability, and upcycling in polyurethane networks.Nature communications · 2026Article
- Mild and metal-free chemical recycling of polyureas via acylation-activated bond cleavage.National science review · 2025Article
- Dynamically crosslinked-interpenetrating networks for sustainable 3D-printed elastomeric foams.Nature communications · 2025Article
- Enhancing the Self-Assembly of Step-Growth Polymers by Narrowing Their Molar Mass Distribution: A Dynamic Bond-Mediated Approach.Angewandte Chemie (International ed. in English) · 2025Article
- Closed-Loop Recyclable and Extrusion Reprocessable Thermosets Enabled by Guanylthiourea Structure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Strain-release driven reactivity of a chiral SuFEx reagent provides stereocontrolled access to sulfinamides, sulfonimidamides, and sulfoximines.Nature communications · 2024Article
- Malleable, Ultrastrong Antibacterial Thermosets Enabled by Guanidine Urea Structure.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Dynamic Covalent Bond-Based Polymer Chains Operating Reversibly with Temperature Changes.Molecules (Basel, Switzerland) · 2024Review
- Ureido Hyperbranched Polymer Modified Urea-Formaldehyde Resin as High-Performance Particleboard Adhesive.Materials (Basel, Switzerland) · 2023Article
- Structure-Reactivity-Property Relationships in Covalent Adaptable Networks.Journal of the American Chemical Society · 2022Review
- Dynamic Bonds: Adaptable Timescales for Responsive Materials.Angewandte Chemie (International ed. in English) · 2022Review
- Reusable Macroporous Oil Sorbent Films from Plastic Wastes.Polymers · 2022Article
- Catalyst-free synthesis of novel 1,5-benzodiazepines and 3,4-dihydroquinoxalines using isocyanide-based one-pot, three- and four-component reactions.RSC advances · 2021Article
- Robust Superamphiphilic Membrane with a Closed-Loop Life Cycle.Advanced materials (Deerfield Beach, Fla.) · 2021Review
- Dynamic multiphase semi-crystalline polymers based on thermally reversible pyrazole-urea bonds.Nature communications · 2019Article
- PEGylated Polyurea Bearing Hindered Urea Bond for Drug Delivery.Molecules (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Hydrolyzable polymers are widely used materials that have found numerous applications in biomedical, agricultural, plastic, and packaging industrials. They usually contain ester and other hydrolyzable bonds, such as anhydride, acetal, ketal, or imine, in their backbone structures. Here, we report the first design of hydrolyzable polyureas bearing dynamic hindered urea bonds (HUBs) that can reversibly dissociate to bulky amines and isocyanates, the latter of which can be further hydrolyzed by water, driving the equilibrium to facilitate the degradation of polyureas. Polyureas bearing 1-tert-butyl-1-ethylurea bonds that show high dynamicity (high bond dissociation rate), in the form of either linear polymers or cross-linked gels, can be completely degraded by water under mild conditions. Given the simplicity and low cost for the production of polyureas by simply mixing multifunctional bulky amines and isocyanates, the versatility of the structures, and the tunability of the degradation profiles of HUB-bearing polyureas, these materials are potentially of very broad applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.