Evidence map›Paper›PMID 25405996›Full record

ArticlePloS one2014

Examining the polymorphisms in the hypoxia pathway genes in relation to outcome in colorectal cancer.

Asan M S Haja Mohideen, Angela Hyde, Jessica Squires, Jing Wang, Elizabeth Dicks, Ban Younghusband, Patrick Parfrey, Roger Green, Sevtap Savas

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.2field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Asan M S Haja MohideenDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Angela HydeDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Jessica SquiresDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Jing WangDivision of Community Health and Humanities, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Elizabeth DicksClinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Ban YounghusbandDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Patrick ParfreyClinical Epidemiology Unit, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Roger GreenDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Sevtap SavasDiscipline of Genetics, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada; Discipline of Oncology, Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL, Canada.
Memorial University of Newfoundland · CA

Funding

Canadian Institutes of Health Research FRN: 110045
6 · The paper itself

Abstract

introductionColorectal cancer is a common malignancy. Identification of genetic prognostic markers may help prognostic estimations in colorectal cancer. Genes that regulate response to hypoxia and other genes that are regulated under the hypoxic conditions have been shown to play roles in cancer progression. In this study, we hypothesized that genetic variations in the hypoxia pathway genes were associated with the risk of outcome in colorectal cancer patients.

methodsThis study was performed in two phases. In the first phase, 49 SNPs from six hypoxia pathway genes (HIF1A, HIF1B, HIF2A, LOX, MIF and CXCL12) in 272 colorectal cancer patients were analyzed. In the second phase, 77 SNPs from seven hypoxia pathway genes (HIF1A, HIF1B, HIF2A, HIF2B, HIF3A, LOX and CXCL12) were analyzed in an additional cohort of 535 patients. Kaplan Meier, Cox univariate and multivariable regression analyses were performed to analyze the relationship between the SNPs and overall survival (OS), disease free survival (DFS) or disease specific survival (DSS). Since this was a hypothesis-generating study, no correction for multiple testing was applied.

resultsIn phase I, one SNP (HIF2A rs11125070) was found to be associated with DFS in multivariable analysis; yet association of a proxy polymorphism (HIF2A rs4953342) was not detected in the phase II patient cohort. In phase II, associations of two SNPs (HIF2A rs4953352 and HIF2B rs12593988) were significant in both OS and DFS multivariable analyses. However, association of HIF2A rs4953352 was not replicated in the phase I cohort using a proxy SNP (HIF2A rs6706003).

conclusionOverall, our study did not find a convincing evidence of association of the investigated polymorphisms with the disease outcomes in colorectal cancer.

Indexed as

HypoxiaPolymorphism, Single NucleotideAdultAgedAged, 80 and overApoptosis Regulatory ProteinsAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsChemokine CXCL12Colorectal NeoplasmsEndothelial PAS Domain-Containing Protein 1FemaleGene FrequencyGenotypeHumansHypoxia-Inducible Factor 1, alpha SubunitApoptosis Regulatory ProteinsARNT protein, humanAryl Hydrocarbon Receptor Nuclear TranslocatorBasic Helix-Loop-Helix ProteinsChemokine CXCL12CXCL12 protein, humanEndothelial PAS Domain-Containing Protein 1HIF1A protein, humanHIF3A protein, humanHypoxia-Inducible Factor 1, alpha SubunitRepressor Proteins

Identifiers

PMID25405996
PMCPMC4236175
OpenAlexW2079732146

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.