ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Medicines, shaken and stirred: a critical review on the ecotoxicology of pharmaceutical mixtures.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- Toxicological effect of acetaminophen, metamizole, and nimesulide cocktail on early development of zebrafish.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2024Article
- Joint Toxicity and Interaction of Carbon-Based Nanomaterials with Co-Existing Pollutants in Aquatic Environments: A Review.International journal of molecular sciences · 2024Review
- Factors Determining the Susceptibility of Fish to Effects of Human Pharmaceuticals.Environmental science & technology · 2023Review
- Article
- Transcriptome signatures of wastewater effluent exposure in larval zebrafish vary with seasonal mixture composition in an effluent-dominated stream.The Science of the total environment · 2023Article
- Integrated Exposure and Algal Ecotoxicological Assessments of Effluents from Secondary and Advanced-Tertiary Wastewater-Treatment Plants.Environmental toxicology and chemistry · 2022Article
- Co-metabolic biodegradation of 4-bromophenol in a mixture of pollutants system by Arthrobacter chlorophenolicus A6.Ecotoxicology (London, England) · 2022Article
- Pharmaceutical pollution of the world's rivers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Pharmaceuticals in treated wastewater induce a stress response in tomato plants.Scientific reports · 2020Article
- Metabolomic Investigations of the Temporal Effects of Exposure to Pharmaceuticals and Personal Care Products and Their Mixture in the Eastern Oyster (Crassostrea virginica).Environmental toxicology and chemistry · 2020Article
- Biotransformation of the Fluorinated Nonsteroidal Anti-Inflammatory Pharmaceutical Flurbiprofen in Activated Sludge Results in Accumulation of a Recalcitrant Fluorinated Aromatic Metabolite.Global challenges (Hoboken, NJ) · 2019Article
- Combined acute ecotoxicity of malathion and deltamethrin to Daphnia magna (Crustacea, Cladocera): comparison of different data analysis approaches.Environmental science and pollution research international · 2018Article
- Risk assessment of an organochlorine pesticide mixture in the surface waters of Qingshitan Reservoir in Southwest China.RSC advances · 2018Article
- Toxicity assessment of five emerging pollutants, alone and in binary or ternary mixtures, towards three aquatic organisms.Environmental science and pollution research international · 2018Article
- Reduced anxiety is associated with the accumulation of six serotonin reuptake inhibitors in wastewater treatment effluent exposed goldfish Carassius auratus.Scientific reports · 2017Article
- Determining potential adverse effects in marine fish exposed to pharmaceuticals and personal care products with the fish plasma model and whole-body tissue concentrations.Environmental pollution (Barking, Essex : 1987) · 2017Article
- Temporal and spatial behavior of pharmaceuticals in Narragansett Bay, Rhode Island, United States.Environmental toxicology and chemistry · 2017Article
- Using Delaunay triangulation and Voronoi tessellation to predict the toxicities of binary mixtures containing hormetic compound.Scientific reports · 2017Article
- Biological Removal of the Mixed Pharmaceuticals: Diclofenac, Ibuprofen, and Sulfamethoxazole Using a Bacterial Consortium.Iranian journal of biotechnology · 2017Article
- Emerging various environmental threats to brain and overview of surveillance system with zebrafish model.Toxicology reports · 2017Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analytical monitoring surveys routinely confirm that organisms in the environment are exposed to complex multi-component pharmaceutical mixtures. We are hence tasked with the challenge to take this into consideration when investigating the ecotoxicology of pharmaceuticals. This review first provides a brief overview of the fundamental approaches for mixture toxicity assessment, which is then followed by a critical review on the empirical evidence that is currently at hand on the ecotoxicology of pharmaceutical mixtures. It is concluded that, while the classical concepts of concentration addition and independent action (response addition) provide a robust scientific footing, several knowledge gaps remain. This includes, in particular, the need for more and better empirical data on the effects of pharmaceutical mixtures on soil organisms as well as marine flora and fauna, and exploring the quantitative consequences of toxicokinetic, toxicodynamic and ecological interactions. Increased focus should be put on investigating the ecotoxicology of pharmaceutical mixtures in environmentally realistic settings.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.