ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2014
Ecological effects of pharmaceuticals in aquatic systems--impacts through behavioural alterations.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 490 citations in OpenAlex.
- Assessing the Mobility Disruption ofInsects · 2026Article
- Z-Drugs in the Environment: A Review.Molecules (Basel, Switzerland) · 2026Review
- Are Behavioral Ecotoxicity Endpoints Relevant at the Population Level? Evidence-Based Insights for Environmental Protection.Environmental science & technology · 2026Review
- Antibiotic use in Chilean salmon aquaculture: antimicrobial resistance, sustainability, and One Health implications.Frontiers in microbiology · 2026Review
- Advances in the evolution of antibiotic resistance risks in hospital wastewater and multibarrier control strategies.Frontiers in microbiology · 2026Review
- Change in activity in Baltic clam (Macoma balthica) exposed to elevated sulphate concentrations.Ecotoxicology (London, England) · 2025Article
- Wastewater remediation of pharmaceuticals with ozone and granular active carbon: a risk-driven approach.Environmental science : water research & technology · 2025Article
- A Double Challenge for Fish: The Combined Stress of Warming and Pharmaceuticals in Aquatic Systems.Journal of xenobiotics · 2025Review
- Impacts of an anxiolytic drug on fish behaviour and habitat use in a natural landscape.Proceedings. Biological sciences · 2025Article
- Pharmacometabolomics Study of Sulfamethoxazole and Trimethoprim in Kidney Transplant Recipients: Real-World Metabolism and Urinary Excretion.Metabolites · 2025Article
- Toxicity of pharmaceutical micropollutants on common carp (Cyprinus carpio) using blood biomarkers.Scientific reports · 2025Article
- Ecotoxicity of Fire Retardants to Zebrafish (Journal of xenobiotics · 2025Article
- Pharmaceuticals and Microplastics in Aquatic Environments: A Comprehensive Review of Pathways and Distribution, Toxicological and Ecological Effects.International journal of environmental research and public health · 2025Review
- Oxidative Stress Biomarkers in Fish Exposed to Environmental Concentrations of Pharmaceutical Pollutants: A Review.Biology · 2025Review
- EthoCRED: a framework to guide reporting and evaluation of the relevance and reliability of behavioural ecotoxicity studies.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Evidence of the impacts of pharmaceuticals on aquatic animal behaviour (EIPAAB): a systematic map and open access database.Environmental evidence · 2025Article
- Presence, removal, and risks of psychopharmaceuticals in wastewater streams.Environmental toxicology and chemistry · 2025Article
- Evaluating the effects of pharmaceutical pollutants on common carp (Frontiers in physiology · 2025Article
- Article
- From prescription to pollution: The ecological consequences of NSAIDs in aquatic ecosystems.Toxicology reports · 2024Review
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The study of animal behaviour is important for both ecology and ecotoxicology, yet research in these two fields is currently developing independently. Here, we synthesize the available knowledge on drug-induced behavioural alterations in fish, discuss potential ecological consequences and report results from an experiment in which we quantify both uptake and behavioural impact of a psychiatric drug on a predatory fish (Perca fluviatilis) and its invertebrate prey (Coenagrion hastulatum). We show that perch became more active while damselfly behaviour was unaffected, illustrating that behavioural effects of pharmaceuticals can differ between species. Furthermore, we demonstrate that prey consumption can be an important exposure route as on average 46% of the pharmaceutical in ingested prey accumulated in the predator. This suggests that investigations of exposure through bioconcentration, where trophic interactions and subsequent bioaccumulation of exposed individuals are ignored, underestimate exposure. Wildlife may therefore be exposed to higher levels of behaviourally altering pharmaceuticals than predictions based on commonly used exposure assays and pharmaceutical concentrations found in environmental monitoring programmes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.