ArticleCerebral cortex (New York, N.Y. : 1991)2015
Task Dependence, Tissue Specificity, and Spatial Distribution of Widespread Activations in Large Single-Subject Functional MRI Datasets at 7T.
Article in Cerebral cortex (New York, N.Y. : 1991), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Highlight results, don't hide them: Enhance interpretation, reduce biases and improve reproducibility.NeuroImage · 2023Pooled it
- A large-scale heterogeneous 3D magnetic resonance brain imaging dataset for self-supervised learning.Scientific data · 2026Article
- A new fMRI quality metric using multi-echo information: Theory, validation and implications.bioRxiv : the preprint server for biology · 2026Article
- The Neural Organization of Visual Information in the Auditory Cortex of the Congenitally Deaf.Human brain mapping · 2026Article
- Study protocol for the Champaign-Urbana population study.Frontiers in neuroimaging · 2026Article
- Regional activity and interregional functional connectivity uniquely contribute to social cognitive judgments during movie-watching.Network neuroscience (Cambridge, Mass.) · 2026Article
- Investigation of the large-scale white-matter functional networks in spinocerebellar ataxia type 3.Quantitative imaging in medicine and surgery · 2025Article
- A Shared Threat-Anticipation Circuit Is Dynamically Engaged at Different Moments by Certain and Uncertain Threat.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- A shared threat-anticipation circuit is dynamically engaged at different moments by certain and uncertain threat.bioRxiv : the preprint server for biology · 2025Article
- Whole-brain, gray, and white matter time-locked functional signal changes with simple tasks and model-free analysis.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Improving the study of brain-behavior relationships by revisiting basic assumptions.Trends in cognitive sciences · 2023Review
- Stability of sensorimotor network sculpts the dynamic repertoire of resting state over lifespan.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Temporal stability of the hemodynamic response function across the majority of human cerebral cortex.Human brain mapping · 2022Article
- A Complex Systems Perspective on Neuroimaging Studies of Behavior and Its Disorders.The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry · 2022Review
- Allostasis as a core feature of hierarchical gradients in the human brain.Network neuroscience (Cambridge, Mass.) · 2022Article
- Imaging faster neural dynamics with fast fMRI: A need for updated models of the hemodynamic response.Progress in neurobiology · 2021Review
- Article
- High-resolution fMRI at 7 Tesla: challenges, promises and recent developments for individual-focused fMRI studies.Current opinion in behavioral sciences · 2021Article
- Anxiety and the Neurobiology of Temporally Uncertain Threat Anticipation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
It was recently shown that when large amounts of task-based blood oxygen level-dependent (BOLD) data are combined to increase contrast- and temporal signal-to-noise ratios, the majority of the brain shows significant hemodynamic responses time-locked with the experimental paradigm. Here, we investigate the biological significance of such widespread activations. First, the relationship between activation extent and task demands was investigated by varying cognitive load across participants. Second, the tissue specificity of responses was probed using the better BOLD signal localization capabilities of a 7T scanner. Finally, the spatial distribution of 3 primary response types--namely positively sustained (pSUS), negatively sustained (nSUS), and transient--was evaluated using a newly defined voxel-wise waveshape index that permits separation of responses based on their temporal signature. About 86% of gray matter (GM) became significantly active when all data entered the analysis for the most complex task. Activation extent scaled with task load and largely followed the GM contour. The most common response type was nSUS BOLD, irrespective of the task. Our results suggest that widespread activations associated with extremely large single-subject functional magnetic resonance imaging datasets can provide valuable information about the functional organization of the brain that goes undetected in smaller sample sizes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.