SynthesisInternational journal of molecular sciences2014
Exploring the role of paraoxonases in the pathogenesis of coronary artery disease: a systematic review.
Synthesis in International journal of molecular sciences, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 45 citations in OpenAlex.
- Cardiovascular Benefits of Phenol-Enriched Virgin Olive Oils: New Insights from the Virgin Olive Oil and HDL Functionality (VOHF) Study.Molecular nutrition & food research · 2018Trial
- Relationship between the oxidative stress biomarkers and coronary heart disease: Pathogenesis to therapeutic aspects.World journal of cardiology · 2026Review
- Molecular Structure of Paraoxonase-1 and Its Modifications in Relation to Enzyme Activity and Biological Functions-A Comprehensive Review.International journal of molecular sciences · 2024Review
- The importance of paraoxonase 1 activity in chronic kidney disease.Renal failure · 2024Review
- Alteration of Blood Oxidative Stress Status in Patients with Thoracic Aortic Dissection: A Pilot Study.Antioxidants (Basel, Switzerland) · 2023Article
- Gender Differences and Cardiometabolic Risk: The Importance of the Risk Factors.International journal of molecular sciences · 2023Review
- The effect of paraoxonase 1 (PON1) gene polymorphisms T(-107)C and L55M and diet composition on serum PON1 activity in women.Archives of endocrinology and metabolism · 2021Article
- Factors associated to serum paraoxonase 1 activity in patients with cardiovascular disease.Archives of endocrinology and metabolism · 2021Article
- The Role ofGlobal medical genetics · 2020Review
- Genetic associations and serum paraoxonase levels with atherosclerosis in western Iranian patients.Molecular biology reports · 2020Article
- Linc-OIP5 working as a ceRNA of miR-616 promotes PON1 expression in HUEVC cells.International journal of clinical and experimental pathology · 2020Article
- Association of Race and Major Adverse Cardiac Events (MACE): The Atherosclerosis Risk in Communities (ARIC) Cohort.Journal of aging research · 2020Article
- Mutual Influences between Nitric Oxide and Paraoxonase 1.Antioxidants (Basel, Switzerland) · 2019Review
- Association of SOD2 A16V and PON2 S311C polymorphisms with polycystic ovary syndrome in Chinese women.Journal of endocrinological investigation · 2019Article
- Paraoxonase 1, HDL Subclasses and Post Surgery Acute Inflammation: A Pilot Study.Antioxidants (Basel, Switzerland) · 2019Article
- Dysfunctional high-density lipoproteins have distinct composition, diminished anti-inflammatory potential and discriminate acute coronary syndrome from stable coronary artery disease patients.Scientific reports · 2017Article
- Association of Paraoxonase-1 Q192R (rs662) Single Nucleotide Variation with Cardiovascular Risk in Coffee Harvesters of Central Colombia.Journal of toxicology · 2017Article
- Chronic Kidney Disease and Disproportionally Increased Cardiovascular Damage: Does Oxidative Stress Explain the Burden?Oxidative medicine and cellular longevity · 2017Review
- Oxidative Stress Genes, Antioxidants and Coronary Artery Disease in Type 2 Diabetes Mellitus.Cardiovascular & hematological agents in medicinal chemistry · 2016Review
- Immunohistochemical analysis of paraoxonases and chemokines in arteries of patients with peripheral artery disease.International journal of molecular sciences · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Paraoxonases (PON) are three enzymes (PON1, PON2 and PON3) that play a role in the organism's antioxidant system; alterations in which are associated with diseases involving oxidative stress. In this review, we summarize the evidence of PON related to the pathogenesis of coronary artery disease (CAD) and atherosclerosis. We searched three electronic databases (PubMed, Scopus and Cochrane Database) with no date limit. All of the articles selected investigated PON enzymatic activity and/or PON gene polymorphisms. The selection focused on PON in relation to atherosclerosis, CAD and myocardial infarction. The exclusion criteria were a sample size <100 patients, non-human studies, editorials and systematic reviews without restrictions on the country of origin. With these criteria, we identified thirty-five prospective studies published between 1986 and 2014 with a total of 28,164 participants. The relationship between PON gene polymorphisms and CAD was not conclusive, but most studies support the concept that alterations in PON1 enzymatic activity levels do influence atheroma formation. Conversely, relationships between PON2 and PON3 vs. CAD have not been extensively investigated. Our review of the current data concludes that the bases of paraoxonases involvement in atherosclerosis are poorly understood and that this issue requires future comprehensive, multi-centered studies.
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