ArticleAnalytical chemistry2014
Acoustofluidic chemical waveform generator and switch.
Article in Analytical chemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Massively parallel microbubble nano-assembly.Nature communications · 2025Article
- Manipulation with sound and vibration: A review on the micromanipulation system based on sub-MHz acoustic waves.Ultrasonics sonochemistry · 2023Review
- Ultrasound-activated ciliary bands for microrobotic systems inspired by starfish.Nature communications · 2021Article
- One-step enzyme kinetics measurement in 3D printed microfluidics devices based on a high-performance single vibrating sharp-tip mixer.Analytica chimica acta · 2021Article
- A Concentration Gradients Tunable Generator with Adjustable Position of the Acoustically Oscillating Bubbles.Micromachines · 2020Article
- On-chip rotational manipulation of microbeads and oocytes using acoustic microstreaming generated by oscillating asymmetrical microstructures.Biomicrofluidics · 2019Article
- Acoustofluidic methods in cell analysis.Trends in analytical chemistry : TRAC · 2019Article
- Tunable microfluidic standing air bubbles and its application in acoustic microstreaming.Biomicrofluidics · 2019Article
- A sharp-edge-based acoustofluidic chemical signal generator.Lab on a chip · 2018Article
- Acoustic Actuation ofJournal of micromechanics and microengineering : structures, devices, and systems · 2018Article
- An electrically-controlled programmable microfluidic concentration waveform generator.Journal of biological engineering · 2018Article
- Neutrophil-inspired propulsion in a combined acoustic and magnetic field.Nature communications · 2017Article
- Mixing high-viscosity fluids via acoustically driven bubbles.Journal of micromechanics and microengineering : structures, devices, and systems · 2017Article
- Microfluidic Hydrodynamic Focusing for Synthesis of Nanomaterials.Nano today · 2016Article
- Acoustofluidic Rotational Manipulation of Cells and Organisms Using Oscillating Solid Structures.Small (Weinheim an der Bergstrasse, Germany) · 2016Article
- Acoustofluidic actuation of in situ fabricated microrotors.Lab on a chip · 2016Article
- Rotational manipulation of single cells and organisms using acoustic waves.Nature communications · 2016Article
- An acoustofluidic sputum liquefier.Lab on a chip · 2015Article
- Selectively manipulable acoustic-powered microswimmers.Scientific reports · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Eliciting a cellular response to a changing chemical microenvironment is central to many biological processes including gene expression, cell migration, differentiation, apoptosis, and intercellular signaling. The nature and scope of the response is highly dependent upon the spatiotemporal characteristics of the stimulus. To date, studies that investigate this phenomenon have been limited to digital (or step) chemical stimulation with little control over the temporal counterparts. Here, we demonstrate an acoustofluidic (i.e., fusion of acoustics and microfluidics) approach for generating programmable chemical waveforms that permits continuous modulation of the signal characteristics including the amplitude (i.e., sample concentration), shape, frequency, and duty cycle, with frequencies reaching up to 30 Hz. Furthermore, we show fast switching between multiple distinct stimuli, wherein the waveform of each stimulus is independently controlled. Using our device, we characterized the frequency-dependent activation and internalization of the β2-adrenergic receptor (β2-AR), a prototypic G-protein coupled receptor (GPCR), using epinephrine. The acoustofluidic-based programmable chemical waveform generation and switching method presented herein is expected to be a powerful tool for the investigation and characterization of the kinetics and other dynamic properties of many biological and biochemical processes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.