ArticlePloS one2014
Oxytocin and vasopressin receptor gene variation as a proximate base for inter- and intraspecific behavioral differences in bonobos and chimpanzees.
Article in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
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- Elephants as an animal model for self-domestication.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Human cooperation and evolutionary transitions in individuality.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Article
- Chimpanzee communities differ in their inter- and intrasexual social relationships.Learning & behavior · 2023Article
- Genetic determinants of individual variation in the superior temporal sulcus of chimpanzees (Pan troglodytes).Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Rhesus monkey sociality is stable across time and linked to variation in the initiation but not receipt of prosocial behavior.American journal of primatology · 2022Article
- The interaction engine: cuteness selection and the evolution of the interactional base for language.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Review
- Plasma Testosterone and Androstenedione Levels Follow the Same Sex-Specific Patterns in the TwoBiology · 2022Article
- Oxytocin and vasotocin receptor variation and the evolution of human prosociality.Comprehensive psychoneuroendocrinology · 2022Article
- Distribution of brain oxytocin and vasopressin V1a receptors in chimpanzees (Pan troglodytes): comparison with humans and other primate species.Brain structure & function · 2022Article
- Differences in the mutual eye gaze of bonobos (Pan paniscus) and chimpanzees (Pan troglodytes).Journal of comparative psychology (Washington, D.C. : 1983) · 2020Article
- AVPR1A variation is linked to gray matter covariation in the social brain network of chimpanzees.Genes, brain, and behavior · 2020Article
- Human Social Evolution: Self-Domestication or Self-Control?Frontiers in psychology · 2020Article
- Aging and sex affect soluble alpha klotho levels in bonobos and chimpanzees.Frontiers in zoology · 2018Article
- Primate social attention: Species differences and effects of individual experience in humans, great apes, and macaques.PloS one · 2018Article
- Bonobos respond prosocially toward members of other groups.Scientific reports · 2017Article
- Social Behavior of Pet Dogs Is Associated with Peripheral OXTR Methylation.Frontiers in psychology · 2017Article
- Microsatellite Polymorphisms Adjacent to the Oxytocin Receptor Gene in Domestic Cats: Association with Personality?Frontiers in psychology · 2017Article
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Authors and funding
6 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent literature has revealed the importance of variation in neuropeptide receptor gene sequences in the regulation of behavioral phenotypic variation. Here we focus on polymorphisms in the oxytocin receptor gene (OXTR) and vasopressin receptor gene 1a (Avpr1a) in chimpanzees and bonobos. In humans, a single nucleotide polymorphism (SNP) in the third intron of OXTR (rs53576 SNP (A/G)) is linked with social behavior, with the risk allele (A) carriers showing reduced levels of empathy and prosociality. Bonobos and chimpanzees differ in these same traits, therefore we hypothesized that these differences might be reflected in variation at the rs53576 position. We sequenced a 320 bp region surrounding rs53576 but found no indications of this SNP in the genus Pan. However, we identified previously unreported SNP variation in the chimpanzee OXTR sequence that differs from both humans and bonobos. Humans and bonobos have previously been shown to have a more similar 5' promoter region of Avpr1a when compared to chimpanzees, who are polymorphic for the deletion of ∼ 360 bp in this region (+/- DupB) which includes a microsatellite (RS3). RS3 has been linked with variation in levels of social bonding, potentially explaining part of the interspecies behavioral differences found in bonobos, chimpanzees and humans. To date, results for bonobos have been based on small sample sizes. Our results confirmed that there is no DupB deletion in bonobos with a sample size comprising approximately 90% of the captive founder population, whereas in chimpanzees the deletion of DupB had the highest frequency. Because of the higher frequency of DupB alleles in our bonobo population, we suggest that the presence of this microsatellite may partly reflect documented differences in levels of sociability found in bonobos and chimpanzees.
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