ArticleMolecules (Basel, Switzerland)2014
Design and synthesis of isosteviol triazole conjugates for cancer therapy.
Article in Molecules (Basel, Switzerland), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed.
- An updated review on 1,2,3-/1,2,4-triazoles: synthesis and diverse range of biological potential.Molecular diversity · 2025Review
- Chronic Use of Artificial Sweeteners: Pros and Cons.Nutrients · 2024Review
- Synthesis and Study of the Structure-Activity Relationship of AntiproliferativePharmaceuticals (Basel, Switzerland) · 2024Article
- Review
- Anti-Cancer Properties ofMolecules (Basel, Switzerland) · 2022Review
- Synthesis and anti-cancer activities of glycosides and glycoconjugates of diterpenoid isosteviol.MedChemComm · 2019Article
- Bioactivity Profile of the Diterpene Isosteviol and its Derivatives.Molecules (Basel, Switzerland) · 2019Review
- Design and Synthesis of C-19 Isosteviol Derivatives as Potent and Highly Selective Antiproliferative Agents.Molecules (Basel, Switzerland) · 2018Article
- Isosteviol Derivative Inhibits Osteoclast Differentiation and Ameliorates Ovariectomy-Induced Osteoporosis.Scientific reports · 2018Article
- Gene expression profiling leads to discovery of correlation of matrix metalloproteinase 11 and heparanase 2 in breast cancer progression.BMC cancer · 2015Article
- Synthesis and anticancer evaluation of complex unsaturated isosteviol-derived triazole conjugates.Future medicinal chemistry · 2015Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
One of the keys for successfully developing drugs against the broad spectrum of cancer cell types is structural diversity. In the current study, we focused on a family of isosteviol derivatives as potential novel antitumor agents. Isosteviol is a tetracyclic diterpenoid obtained by acid hydrolysis of steviol glycoside extracts isolated from abundant Stevia rebaudiana plants. In this work, we have designed and synthesized a panel of isosteviol triazole conjugates using "click" chemistry methodology. Evaluation of these compounds against a series of cancer cell lines derived from primary and metastatic tumors demonstrated that these conjugates exhibit cytotoxic activities with IC50 in the low μM range. In addition, their anti-proliferative activities are cancer cell type specific. Taken together, our studies underscore the importance of structural diversity in achieving cancer cell type specific drug development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.