Evidence map›Paper›PMID 25405101›Full record

ArticleFrontiers in oncology2014

National Cancer Institute's Cancer Disparities Research Partnership Program: Experience and Lessons Learned.

Rosemary S L Wong, Bhadrasain Vikram, Frank S Govern, Daniel G Petereit, Patrick D Maguire, Maggie R Clarkson, Dwight E Heron, C Norman Coleman

Abstract read
In one paragraph

Article in Frontiers in oncology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Enhancing Career Paths for Tomorrow's Radiation Oncologists.International journal of radiation oncology, biology, physics · 2019
    Review
  6. Article
  7. Institutional Alliances to Reduce Cancer Disparities in Chicago.Journal of health care for the poor and underserved · 2016
    Article
  8. Review
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rosemary S L WongRadiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Rockville, MD , USA.
Bhadrasain VikramRadiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Rockville, MD , USA.
Frank S GovernRadiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Rockville, MD , USA.
Daniel G PetereitWalking Forward Program, Rapid City Regional Hospital , Rapid City, SD , USA.
Patrick D MaguireCoastal Carolina Radiation Oncology , Wilmington, NC , USA.
Maggie R ClarksonSinging River Health System , Pascagoula, MS , USA.
Dwight E HeronUniversity of Pittsburgh Medical Center McKeesport , McKeesport, PA , USA.
C Norman ColemanRadiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute , Rockville, MD , USA.

Funding

Enhancing Native American Participation in RT TrialsU56CA099010 · NCI · RAPID CITY REGIONAL HOSPITAL · PI PETEREIT, DANIEL G · 2002 to 2008
$6.2M
UPMC McKeesport/ROCOG Radiation Oncology Minorities Outreach GroupU56CA105486 · NCI · UPMC MC KEESPORT · PI HERON, DWIGHT E · 2003 to 2008
$4.6M
Walking Forward - American Indian Participation in Cancer Clinical TrialsU54CA142157 · NCI · RAPID CITY REGIONAL HOSPITAL · PI PETEREIT, DANIEL G · 2009 to 2013
$4.1M
MS/AL Radiation Oncology Research PartnershipU56CA105478 · NCI · SINGING RIVER HEALTH SYSTEM · PI CLARKSON, JAMES E. · 2003 to 2008
$3.7M
Improving Cancer Outcomes for African-AmericansU56CA105329 · NCI · NEW HANOVER REGIONAL MEDICAL CENTER · PI MAGUIRE, PATRICK DAVID · 2003 to 2007
$3.6M
MS/AL RADIATION ONCOLOGY RESEARCH PARTNERSHIPU54CA142158 · NCI · SINGING RIVER HEALTH SYSTEM · PI CLARKSON, JAMES E. · 2009 to 2012
$1.8M
Improving Cancer Outcomes for Underserved Populations in SE North CarolinaU54CA142152 · NCI · NEW HANOVER REGIONAL MEDICAL CENTER · PI MAGUIRE, PATRICK DAVID · 2009 to 2013
$1.6M
NCI NIH HHS U54 CA142152NCI NIH HHS U54 CA142157NCI NIH HHS U54 CA142158NCI NIH HHS U56 CA099010NCI NIH HHS U56 CA105329NCI NIH HHS U56 CA105478NCI NIH HHS U56 CA105486
6 · The paper itself

Abstract

purposeTo increase access of underserved/health disparities communities to National Cancer Institute (NCI) clinical trials, the Radiation Research Program piloted a unique model - the Cancer Disparities Research Partnership (CDRP) program. CDRP targeted community hospitals with a limited past NCI funding history and provided funding to establish the infrastructure for their clinical research program.

methodsInitially, 5-year planning phase funding was awarded to six CDRP institutions through a cooperative agreement (U56). Five were subsequently eligible to compete for 5-year implementation phase (U54) funding and three received a second award. Additionally, the NCI Center to Reduce Cancer Health Disparities supported their U56 patient navigation programs.

resultsCommunity-based hospitals with little or no clinical trials experience required at least a year to develop the infrastructure and establish community outreach/education and patient navigation programs before accrual to clinical trials could begin. Once established, CDRP sites increased their yearly patient accrual mainly to NCI-sponsored cooperative group trials (~60%) and Principal Investigator/mentor-initiated trials (~30%). The total number of patients accrued on all types of trials was 2,371, while 5,147 patients received navigation services.

conclusionDespite a historical gap in participation in clinical cancer research, underserved communities are willing/eager to participate. Since a limited number of cooperative group trials address locally advanced diseases seen in health disparities populations; this shortcoming needs to be rectified. Sustainability for these programs remains a challenge. Addressing these gaps through research and public health mechanisms may have an important impact on their health, scientific progress, and efforts to increase diversity in NCI clinical trials.

Indexed as

access to clinical trialscancer disparitiesclinical researchpatient accrualunderserved populations

Identifiers

PMID25405101
PMCPMC4217306

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.