ArticleJournal of oral microbiology2014
Children with severe early childhood caries: streptococci genetic strains within carious and white spot lesions.
Article in Journal of oral microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 18 citations in OpenAlex.
- Evaluation of ViableInternational journal of clinical pediatric dentistry · 2025Article
- Intraspecies interactions ofmSphere · 2024Article
- Aesthetic impact of resin infiltration and its mechanical effect on ceramic bonding for white spot lesions.BMC oral health · 2024Article
- Evaluation of Salivary Immunoglobulin A Level and Its Correlation with Severity of Early Childhood Caries: An Original Research.International journal of clinical pediatric dentistry · 2024Article
- Comparison of biofilm models for producing artificial active white spot lesions.Journal of applied oral science : revista FOB · 2024Article
- Intraspecies interactions ofbioRxiv : the preprint server for biology · 2023Article
- Anti-Bacterial Effect of Cannabidiol against the CariogenicInternational journal of molecular sciences · 2022Article
- Global Noncoding microRNA Profiling in Mice Infected with Partial Human Mouth Microbes (PAHMM) Using an Ecological Time-Sequential Polybacterial Periodontal Infection (ETSPPI) Model Reveals Sex-Specific Differential microRNA Expression.International journal of molecular sciences · 2022Article
- Review
- Metagenome sequencing-based strain-level and functional characterization of supragingival microbiome associated with dental caries in children.Journal of oral microbiology · 2019Article
- Transmission patterns of Streptococcus mutans demonstrated by a combined rep-PCR and MLST approach.Clinical oral investigations · 2018Article
- Genetic Diversity and Evidence for Transmission of Streptococcus mutans by DiversiLab rep-PCR.Journal of microbiological methods · 2016Article
Corrections and comments
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Authors and funding
19 authors at 1 institution in 1 country.
Funding
Abstract
BACKGROUND AND
objectivesMutans streptococci (MS) are one of the major microbiological determinants of dental caries. The objectives of this study are to identify distinct MS and non-MS streptococci strains that are located at carious sites and non-carious enamel surfaces in children with severe early childhood caries (S-ECC), and assess if cariogenic MS and non-cariogenic streptococci might independently exist as primary bacterial strains on distinct sites within the dentition of individual children.
designDental plaque from children (N=20; aged 3-6) with S-ECC was collected from carious lesions (CLs), white spot lesions (WSLs) and non-carious enamel surfaces. Streptococcal isolates (N=10-20) from each site were subjected to polymerase chain reaction (PCR) to identify MS, and arbitrarily primed-PCR for assignment of genetic strains. Primary strains were identified as ≥50% of the total isolates surveyed at any site. In several cases, strains were characterized for acidurity using ATP-driven bioluminescence and subjected to PCR-determination of potential MS virulence products. Identification of non-MS was determined by 16S rRNA gene sequencing.
resultsSixty-four independent MS or non-MS streptococcal strains were identified. All children contained 1-6 strains. In many patients (N=11), single primary MS strains were identified throughout the dentition. In other patients (N=4), primary MS strains were identified within CLs that were distinct from primary strains found on enamel. Streptococcus gordonii strains were identified as primary strains on enamel or WSLs in four children, and in general were less aciduric than MS strains.
conclusionsMany children with S-ECC contained only a single primary MS strain that was present in both carious and non-carious sites. In some cases, MS and non-cariogenic S. gordonii strains were found to independently exist as dominant strains at different locations within the dentition of individual children, and the aciduric potential of these strains may influence susceptibility in the development of CLs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.