ReviewFrontiers in plant science2014
2-Oxoglutarate-dependent dioxygenases in the biosynthesis of simple coumarins.
Review in Frontiers in plant science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Signaling Pathways Involved in the Neuroprotective Effect of Osthole: Evidence and Mechanisms.Molecular neurobiology · 2024Pooled it
- Antibacterial phenolic compounds from the flowering plants of Asia and the Pacific: coming to the light.Pharmaceutical biology · 2024Review
- Combined metabolome and transcriptome reveal HmF6'H1 regulating simple coumarin accumulation against powdery mildew infection in Heracleum moellendorffii Hance.BMC plant biology · 2024Article
- Coumarin-Synthetic Methodologies, Pharmacology, and Application as Natural Fluorophore.Topics in current chemistry (Cham) · 2024Review
- A Review of the Ethnobotanical Use, Chemistry and Pharmacological Activities of Constituents Derived from the Plant GenusMetabolites · 2024Review
- Common and specific genetic basis of metabolite-mediated drought responses in rice.Stress biology · 2024Article
- A Review on the Morphology, Cultivation, Identification, Phytochemistry, and Pharmacology ofMolecules (Basel, Switzerland) · 2023Review
- Detection of Coumarin Derivatives ofJournal of pharmacy & bioallied sciences · 2023Article
- Metabolomics analysis reveals metabolite changes during freeze-drying and oven-drying of Angelica dahurica.Scientific reports · 2023Article
- Genome-Wide Identification of 2-Oxoglutarate and Fe (II)-Dependent Dioxygenase (2ODD-C) Family Genes and Expression Profiles under Different Abiotic Stresses inPlants (Basel, Switzerland) · 2023Article
- Genome and systems biology of Melilotus albus provides insights into coumarins biosynthesis.Plant biotechnology journal · 2022Article
- Recent insights on gene expression studies onPhysiology and molecular biology of plants : an international journal of functional plant biology · 2022Review
- Natural Coumarins: Exploring the Pharmacological Complexity and Underlying Molecular Mechanisms.Oxidative medicine and cellular longevity · 2021Review
- Isofraxidin: Synthesis, Biosynthesis, Isolation, Pharmacokinetic and Pharmacological Properties.Molecules (Basel, Switzerland) · 2020Review
- Iron and Phosphate Deficiency Regulators Concertedly Control Coumarin Profiles inFrontiers in plant science · 2019Article
- Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses.Natural product reports · 2018Review
- Article
- Identification and functional characterization of a p-coumaroyl CoA 2'-hydroxylase involved in the biosynthesis of coumarin skeleton from Peucedanum praeruptorum Dunn.Plant molecular biology · 2017Article
- Cloning, Functional Characterization and Site-Directed Mutagenesis of 4-Coumarate: Coenzyme A Ligase (4CL) Involved in Coumarin Biosynthesis inFrontiers in plant science · 2017Article
- Glycosylation Is a Major Regulator of Phenylpropanoid Availability and Biological Activity in Plants.Frontiers in plant science · 2016Review
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Coumarins are natural plant products that have been the subject of extensive phytochemical and pharmacological research studies in the past few decades. The core structure of coumarins is derived from the respective cinnamates via ortho-hydroxylation of the aromatic ring, trans/cis isomerization, and lactonization. Various substitution patterns of coumarins have been reported, whereas the biosynthesis of coumarins remains elusive. Ortho-hydroxylation is a key step in simple coumarin biosynthesis as a branch point from the lignin biosynthetic pathway. 2-Oxoglutarate-dependent dioxygenases (2OGDs) from plants convert cinnamate derivatives into simple coumarins through the process of ortho-hydroxylation. This review describes the 2OGDs involved in coumarin biosynthesis and their substrate specificities.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.