ArticleFrontiers in psychiatry2014
Meta-analyses of developing brain function in high-risk and emerged bipolar disorder.
Article in Frontiers in psychiatry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Alterations in Task-Related Brain Activation in Children, Adolescents and Young Adults at Familial High-Risk for Schizophrenia or Bipolar Disorder - A Systematic Review.Frontiers in psychiatry · 2020Pooled it
- Early Family Intervention for Youth at Risk for Bipolar Disorder: Psychosocial and Neural Mediators of Outcome.Current neuropharmacology · 2023Trial
- Neural changes in youth at high risk for bipolar disorder undergoing family-focused therapy or psychoeducation.Bipolar disorders · 2021Trial
- Early intervention for youth at high risk for bipolar disorder: A multisite randomized trial of family-focused treatment.Early intervention in psychiatry · 2019Trial
- Regional cerebellar structural deficits distinguish psychostimulant-free ADHD youth with and without familial risk for bipolar I disorder: a cross-sectional morphometric analysis.Journal of child psychology and psychiatry, and allied disciplines · 2026Article
- Deficits in sustained attention in adolescents with bipolar disorder during their first manic episode.Journal of affective disorders · 2023Article
- Assessing Relationships Among Impulsive Sensation Seeking, Reward Circuitry Activity, and Risk for Psychopathology: A Functional Magnetic Resonance Imaging Replication and Extension Study.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Article
- Progress in diagnosis and treatment of bipolar disorder among children and adolescents: an international perspective.Evidence-based mental health · 2018Review
- Decreased Functional Connectivity in Insular Subregions in Depressive Episodes of Bipolar Disorder and Major Depressive Disorder.Frontiers in neuroscience · 2018Article
- The International Society for Bipolar Disorders Task Force report on pediatric bipolar disorder: Knowledge to date and directions for future research.Bipolar disorders · 2017Review
- Longitudinal relationships among activity in attention redirection neural circuitry and symptom severity in youth.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2017Article
- Neural Markers in Pediatric Bipolar Disorder and Familial Risk for Bipolar Disorder.Journal of the American Academy of Child and Adolescent Psychiatry · 2017Article
- Comparing Brain Morphometry Across Multiple Childhood Psychiatric Disorders.Journal of the American Academy of Child and Adolescent Psychiatry · 2016Article
- Neural Correlates of Irritability in Disruptive Mood Dysregulation and Bipolar Disorders.The American journal of psychiatry · 2016Article
- Altered neural function to happy faces in adolescents with and at risk for depression.Journal of affective disorders · 2016Article
- Antidepressants, genetic risk, and the prevention of bipolar disorder.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIdentifying early markers of brain function among those at high risk (HR) for pediatric bipolar disorder (PBD) could serve as a screening measure when children and adolescents present with subsyndromal clinical symptoms prior to the conversion to bipolar disorder. Studies on the offspring of patients with bipolar disorder who are genetically at HR have each been limited in establishing a biomarker, while an analytic review in summarizing the findings offers an improvised opportunity toward that goal.
methodsAn activation likelihood estimation (ALE) meta-analysis of mixed cognitive and emotional activities using the GingerALE software from the BrainMap Project was completed. The meta-analysis of all fMRI studies contained a total of 29 reports and included PBD, HR, and typically developing (TD) groups.
resultsThe HR group showed significantly greater activation relative to the TD group in the right DLPFC-insular-parietal-cerebellar regions. Similarly, the HR group exhibited greater activity in the right DLPFC and insula as well as the left cerebellum compared to patients with PBD. Patients with PBD, relative to TD, showed greater activation in regions of the right amygdala, parahippocampal gyrus, medial PFC, left ventral striatum, and cerebellum and lower activation in the right VLPFC and the DLPFC.
conclusionThe HR population showed increased activity, presumably indicating greater compensatory deployment, in relation to both the TD and the PBD, in the key cognition and emotion-processing regions, such as the DLPFC, insula, and parietal cortex. In contrast, patients with PBD, relative to HR and TD, showed decreased activity, which could indicate a decreased effort in multiple PFC regions in addition to widespread subcortical abnormalities, which are suggestive of a more entrenched disease process.
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