ArticleFrontiers in neuroengineering2014
Real-time in vivo optogenetic neuromodulation and multielectrode electrophysiologic recording with NeuroRighter.
Article in Frontiers in neuroengineering, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- A Systematic Review of Closed-Loop Feedback Techniques in Sleep Studies-Related Issues and Future Directions.Sensors (Basel, Switzerland) · 2020Pooled it
- Beyond-local neural information processing in neuronal networks.Computational and structural biotechnology journal · 2024Article
- Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization.Research square · 2024Article
- Refining Brain Stimulation Therapies: An Active Learning Approach to Personalization.bioRxiv : the preprint server for biology · 2024Article
- Irregular optogenetic stimulation waveforms can induce naturalistic patterns of hippocampal spectral activity.Journal of neural engineering · 2024Article
- Optogenetic modulation of hippocampal oscillations ameliorates spatial cognition and hippocampal dysrhythmia following early-life seizures.Neurobiology of disease · 2023Article
- Tracking motion kinematics and tremor with intrinsic oscillatory property of instrumental mechanics.Bioengineering & translational medicine · 2023Article
- A Review: Research Progress of Neural Probes for Brain Research and Brain-Computer Interface.Biosensors · 2022Review
- Flexible Neural Probes with Electrochemical Modified Microelectrodes for Artifact-Free Optogenetic Applications.International journal of molecular sciences · 2021Article
- Artifact-free and high-temporal-resolution in vivo opto-electrophysiology with microLED optoelectrodes.Nature communications · 2020Article
- Optogenetic entrainment of neural oscillations with hybrid fiber probes.Journal of neural engineering · 2018Article
- Multimed: An Integrated, Multi-Application Platform for the Real-Time Recording and Sub-Millisecond Processing of Biosignals.Sensors (Basel, Switzerland) · 2018Article
- A Compact Closed-Loop Optogenetics System Based on Artifact-Free Transparent Graphene Electrodes.Frontiers in neuroscience · 2018Article
- Optogenetic Modulation of a Minor Fraction of Parvalbumin-Positive Interneurons Specifically Affects Spatiotemporal Dynamics of Spontaneous and Sensory-Evoked Activity in Mouse Somatosensory Cortex in Vivo.Cerebral cortex (New York, N.Y. : 1991) · 2017Article
- Utah optrode array customization using stereotactic brain atlases and 3-D CAD modeling for optogenetic neocortical interrogation in small rodents and nonhuman primates.Neurophotonics · 2017Article
- Closed Loop Experiment Manager (CLEM)-An Open and Inexpensive Solution for Multichannel Electrophysiological Recordings and Closed Loop Experiments.Frontiers in neuroscience · 2017Article
- Efficacy of nonselective optogenetic control of the medial septum over hippocampal oscillations: the influence of speed and implications for cognitive enhancement.Physiological reports · 2016Article
- Erratum to: Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Article
- Implantable neurotechnologies: bidirectional neural interfaces--applications and VLSI circuit implementations.Medical & biological engineering & computing · 2016Review
- Mechanics of mouse ocular motor plant quantified by optogenetic techniques.Journal of neurophysiology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Optogenetic channels have greatly expanded neuroscience's experimental capabilities, enabling precise genetic targeting and manipulation of neuron subpopulations in awake and behaving animals. However, many barriers to entry remain for this technology - including low-cost and effective hardware for combined optical stimulation and electrophysiologic recording. To address this, we adapted the open-source NeuroRighter multichannel electrophysiology platform for use in awake and behaving rodents in both open and closed-loop stimulation experiments. Here, we present these cost-effective adaptations, including commercially available LED light sources; custom-made optical ferrules; 3D printed ferrule hardware and software to calibrate and standardize output intensity; and modifications to commercially available electrode arrays enabling stimulation proximally and distally to the recording target. We then demonstrate the capabilities and versatility of these adaptations in several open and closed-loop experiments, demonstrate spectrographic methods of analyzing the results, as well as discuss artifacts of stimulation.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.