Evidence map›Paper›PMID 25404901›Full record

ArticleFrontiers in behavioral neuroscience2014

Nocebo effect in randomized clinical trials of antidepressants in children and adolescents: systematic review and meta-analysis.

Johanna Carolina Rojas-Mirquez, Milton Jose Max Rodriguez-Zuñiga, Francisco Javier Bonilla-Escobar, Herney Andres Garcia-Perdomo, Mike Petkov, Lino Becerra, David Borsook, Clas Linnman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in behavioral neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 4 pooled it
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Johanna Carolina Rojas-MirquezThe Pain and Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesiology, Perioperative and Pain Medicine, The Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School , Waltham, MA , USA ; Grupo de Epidemiología del Trauma y las Lesiones, Universidad del Valle , Cali , Colombia.
Milton Jose Max Rodriguez-ZuñigaThe Pain and Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesiology, Perioperative and Pain Medicine, The Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School , Waltham, MA , USA.
Francisco Javier Bonilla-EscobarInstituto Cisalva, School of Public Health, Universidad del Valle , Cali , Colombia ; Cochrane Center, Universidad del Valle , Cali , Colombia.
Herney Andres Garcia-PerdomoCochrane Center, Universidad del Valle , Cali , Colombia.
Mike PetkovThe Pain and Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesiology, Perioperative and Pain Medicine, The Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School , Waltham, MA , USA.
Lino BecerraThe Pain and Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesiology, Perioperative and Pain Medicine, The Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School , Waltham, MA , USA.
David BorsookThe Pain and Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesiology, Perioperative and Pain Medicine, The Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School , Waltham, MA , USA.
Clas LinnmanThe Pain and Analgesia Imaging Neuroscience (P.A.I.N.) Group, Department of Anesthesiology, Perioperative and Pain Medicine, The Center for Pain and the Brain, Boston Children's Hospital, Harvard Medical School , Waltham, MA , USA.
Center for Pain and the Brain · USHarvard University · USUniversidad del Valle · CO

Funding

Molecular and Functional PET-fMRI Measures of Placebo Analgesia in MigraineR21AT007530 · NCCIH · MASSACHUSETTS GENERAL HOSPITAL · PI BORSOOK, DAVID · 2012 to 2013
$468k
NCCIH NIH HHS R21 AT007530
6 · The paper itself

Abstract

objectiveTo compare the incidence of adverse events between active and placebo arms of randomized clinical trials in depressive children and adolescents (C&A) with antidepressant treatments, in order to look for similarities in both groups that allow to establish a possible nocebo effect.

methodsSystematic search strategy (January 1974-March 2013) in electronic databases, conference abstracts, and reference list of systematic reviews and included studies to identify parallel randomized placebo-controlled trials of antidepressants in C&A (<19 years) with major depressive disorder, and one or more interventions of any orally administered antidepressant. The pooled adverse events were calculated based on a fixed-effect model and statistical analysis involved the risk ratio (RR) of adverse events, with 95% confidence intervals (95% CI).

resultsSixteen studies were included in the review, of which seven studies with a sample of 1911 patients had data to include in the meta-analysis. There was similar risk for the incidence of adverse events between non-active and active group (global RR 1.04, 95% CI: 0.97-1.11).

conclusionDepressive C&A allocated to placebo or active group had similar risk to develop adverse events. These similarities in both groups are attributed to the nocebo effect. It is of note that defining "nocebo" effects is challenging in clinical populations because adverse effects may be attributed to the intervention or may be manifestation of the disease itself. The inclusion of a no-treatment arm may be warranted. Nocebo effects are likely when adverse events of placebo mimic the adverse events of active treatment, as was the case here.

Indexed as

adolescentsantidepressantschildrenmeta-analysisnocebo

Identifiers

PMID25404901
PMCPMC4217505
OpenAlexW2130807231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.