Evidence map›Paper›PMID 25404660›Full record

ArticleDiabetes care2014

High calorie intake is associated with worsening insulin resistance and β-cell function in Hispanic women after gestational diabetes mellitus.

Zhanghua Chen, Richard M Watanabe, Daniel O Stram, Thomas A Buchanan, Anny H Xiang

Open access · bronzeAbstract read
In one paragraph

Article in Diabetes care, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

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  10. Tryptophanylation of insulin receptor by WARS attenuates insulin signaling.Cellular and molecular life sciences : CMLS · 2024
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  14. Metabolic Characteristics of Gestational Diabetes Mellitus and the Effects on Pregnancy Outcomes.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Zhanghua ChenDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Richard M WatanabeDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA Department of Physiology and Biophysics, University of Southern California, Los Angeles, CA Diabetes & Obesity Research Institute, University of Southern California, Los Angeles, CA.
Daniel O StramDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Thomas A BuchananDiabetes & Obesity Research Institute, University of Southern California, Los Angeles, CA Department of Medicine, Division of Diabetes and Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, CA.
Anny H XiangDepartment of Research & Evaluation, Kaiser Permanente Southern California, Pasadena, CA anny.h.xiang@kp.org.
University of Southern California · USKaiser Permanente · US

Funding

ZOPOLRESTAT IN NORMOTENSIVE, TYPE 1 DIA WITH INCIPIENT NEPHROPATHYM01RR000043 · NCRR · UNIVERSITY OF SOUTHERN CALIFORNIA · PI ZAIA, JOHN A · 1985 to 2010
$76.4M
Southern California Clinical and Translational Science InstituteUL1TR000130 · NCATS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 2012 to 2015
$36.0M
PATHOGENESIS OF TYPE 2 DIABETES IN LATINO WOMENR01DK046374 · NIDDK · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BUCHANAN, THOMAS A · 1993 to 2006
$2.6M
NCATS NIH HHS UL1 TR000130NCATS NIH HHS UL1-TR-000130NCRR NIH HHS M01 RR000043NCRR NIH HHS M01-RR-000043NIDDK NIH HHS R01 DK046374NIDDK NIH HHS R01-DK-046374
6 · The paper itself

Abstract

objectiveTo assess associations between dietary intake and rates of change in insulin resistance and β-cell function in Hispanic women with prior gestational diabetes mellitus (GDM). RESEARCH DESIGN AND

methodsSixty-two nondiabetic Hispanic women with pregnancies complicated by GDM completed oral and intravenous glucose tolerance tests and bioelectrical impedance measurements of body fat every 12-15 months postpartum for up to 12 years. Self-reported dietary intake was collected at all visits by structured food frequency questionnaires developed for Hispanics. Mixed-effects models were used to assess the relationship between dietary intake and rates of change in metabolic outcomes during follow-up.

resultsThe median length of follow-up from the first postpartum evaluation was 8.0 years (interquartile range 4.5-10.8 years). At baseline, women were 32 ± 5.7 years old and had a median calorie intake of 2,091 kcal/day. Over the course of follow-up, dietary intake did not change significantly. Higher baseline calorie intake was associated with a faster decline in insulin sensitivity, measured by the insulin sensitivity index (SI) (P = 0.029), and β-cell compensation, measured by the disposition index (DI) (P = 0.027), over time. These associations remained after adjustment for baseline characteristics; changes in BMI, calorie intake, levels of physical activity; and additional pregnancies during the follow-up period. The median rates were -0.06 vs. -0.02 units/year for SI and -810 vs. -692 units/year for DI for women with baseline calorie intake above versus below the cohort median.

conclusionsHigh calorie intake is associated with a faster decline in insulin sensitivity and β-cell compensation in Hispanic women who are at high risk for type 2 diabetes, independent of adiposity.

Indexed as

Diabetes, GestationalInsulin ResistancePostpartum PeriodAdultBody CompositionCohort StudiesDiabetes Mellitus, Type 2Disease ProgressionElectric ImpedanceEnergy IntakeFemaleGlucose Tolerance TestHispanic or LatinoHumansInsulin-Secreting CellsPregnancy

Identifiers

PMID25404660
PMCPMC4237976
OpenAlexW2135034207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.