ReviewDigestive diseases and sciences2015
Recent advances in cirrhotic cardiomyopathy.
Review in Digestive diseases and sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- SGLT2 Inhibitors and Liver Cirrhosis: Hype or Hope?Life (Basel, Switzerland) · 2025Review
- [Cirrhotic cardiomyopathy – Clinically fact or academic curiosity? Review: Part 1: definition, epidemiology, pathology and clinical manifestations]Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina) · 2024Article
- What's New in Cirrhotic Cardiomyopathy?-Review Article.Journal of personalized medicine · 2021Review
- Assessment of biventricular function in patients with hepatopulmonary syndrome.The international journal of cardiovascular imaging · 2021Article
- Autonomic regulation of imbalance-induced myocardial fibrosis and its mechanism in rats with cirrhosis.Experimental and therapeutic medicine · 2021Article
- QTc prolongation in patients of cirrhosis and its relation with disease severity: An observational study from a rural teaching hospital.Journal of family medicine and primary care · 2020Article
- Myocardial structural and functional changes in patients with liver cirrhosis awaiting liver transplantation: a comprehensive cardiovascular magnetic resonance and echocardiographic study.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance · 2020Article
- Cardiac Imaging in Liver Transplantation Candidates: Current Knowledge and Future Perspectives.Journal of clinical medicine · 2019Review
- Prevalence and clinical presentation of cirrhotic cardiomyopathy: A single centre experience from southern India.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2019Article
- Cirrhotic cardiomyopathy: the liver affects the heart.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2019Review
- TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease.American journal of physiology. Heart and circulatory physiology · 2018Article
- Tp-e Interval, Tp-e/QTc Ratio, and Fragmented QRS Are Correlated with the Severity of Liver Cirrhosis.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2017Article
- Diastolic dysfunction in cirrhosis.Heart failure reviews · 2016Review
- Rethinking the role of non-selective beta blockers in patients with cirrhosis and portal hypertension.World journal of hepatology · 2016Review
- Non-selective β-blockers in advanced cirrhosis: a critical review of the effects on overall survival and renal function.BMJ open gastroenterology · 2016Article
- Cirrhotic cardiomyopathy.World journal of gastroenterology · 2015Review
- A case-cohort study of left ventricular diastolic dysfunction in patients with cirrhosis: the liver-heart axis.Annals of gastroenterologyArticle
- Prevalence of cirrhotic cardiomyopathy according to different diagnostic criteria: alterations in ultrasonographic parameters of both left and right ventricles before and after stress.Annals of gastroenterologyArticle
- Left Ventricular Diastolic Dysfunction is Associated with Renal Dysfunction, Poor Survival and Low Health Related Quality of Life in Cirrhosis.Journal of clinical and experimental hepatologyArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cirrhotic cardiomyopathy, a cardiac dysfunction presented in patients with cirrhosis, represents a recently recognized clinical entity. It is characterized by altered diastolic relaxation, impaired contractility, and electrophysiological abnormalities, in particular prolongation of the QT interval. Several mechanisms seem to be involved in the pathogenesis of cirrhotic cardiomyopathy, including impaired function of beta-receptors, altered transmembrane currents, and overproduction of cardiodepressant factors, like nitric oxide, tumor necrosis factor α, and endogenous cannabinoids. Diastolic dysfunction is the first manifestation of cirrhotic cardiomyopathy and reflects the increased stiffness of the cardiac mass, which leads to delayed left ventricular filling. On the other hand, systolic incompetence is presented later, is usually unmasked during pharmacological or physical stress, and predisposes to the development of hepatorenal syndrome. The prolongation of QT is found in about 50 % of cirrhotic patients, but rarely leads to fatal arrhythmias. Cirrhotics with blunted cardiac function seem to have poorer survival rates compared to those without, and the risk is particularly increased during the insertion of transjugular intrahepatic portosystemic shunt or liver transplantation. Till now, there is no specific treatment for the management of cirrhotic cardiomyopathy. New agents, targeting to its pathogenetical mechanisms, may play some role as future therapeutic options.
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