ArticleJournal of immunology (Baltimore, Md. : 1950)2015
Mammalian target of rapamycin complex 2 regulates invariant NKT cell development and function independent of promyelocytic leukemia zinc-finger.
Article in Journal of immunology (Baltimore, Md. : 1950), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 52 citations in OpenAlex.
- Metabolic control of innate-like T cells.Nature reviews. Immunology · 2026Review
- PTEN directs developmental and metabolic signaling for innate-like T cell fate and tissue homeostasis.Nature cell biology · 2022Article
- NKT cells adopt a glutamine-addicted phenotype to regulate their homeostasis and function.Cell reports · 2022Article
- Vam6 reduces iNKT cell function in tumorFrontiers in immunology · 2022Article
- Calcium signals regulate the functional differentiation of thymic iNKT cells.The EMBO journal · 2021Article
- Differential controls of MAIT cell effector polarization by mTORC1/mTORC2 via integrating cytokine and costimulatory signals.Nature communications · 2021Article
- Metabolism in Invariant Natural Killer T Cells: An Overview.Immunometabolism · 2021Article
- Negative control of diacylglycerol kinase ζ-mediated inhibition of T cell receptor signaling by nuclear sequestration in mice.European journal of immunology · 2020Article
- mTOR signaling at the crossroads of environmental signals and T-cell fate decisions.Immunological reviews · 2020Review
- The "other" mTOR complex: New insights into mTORC2 immunobiology and their implications.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2019Review
- Keap1-Nrf2 System Plays an Important Role in Invariant Natural Killer T Cell Development and Homeostasis.Cell reports · 2019Article
- The Protein Phosphatase Shp1 Regulates Invariant NKT Cell Effector Differentiation Independently of TCR and Slam Signaling.Journal of immunology (Baltimore, Md. : 1950) · 2019Article
- Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The ins and outs of type I iNKT cell development.Molecular immunology · 2019Review
- The role of mTOR-mediated signals during haemopoiesis and lineage commitment.Biochemical Society transactions · 2018Review
- Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- The differentiation of ROR-γt expressing iNKT17 cells is orchestrated by Runx1.Scientific reports · 2017Article
- MenTORing Immunity: mTOR Signaling in the Development and Function of Tissue-Resident Immune Cells.Immunity · 2017Review
- Temporal regulation of Wnt/β-catenin signaling is important for invariant NKT cell development and terminal maturation.Molecular immunology · 2017Article
- Applying the TOR(C)QUE in iNKT cells: A new twist in an old tale.European journal of immunology · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
The mammalian target of rapamycin (mTOR) senses and incorporates different environmental cues via the two signaling complexes mTOR complex 1 (mTORC1) and mTORC2. As a result, mTOR controls cell growth and survival, and also shapes different effector functions of the cells including immune cells such as T cells. We demonstrate in this article that invariant NKT (iNKT) cell development is controlled by mTORC2 in a cell-intrinsic manner. In mice deficient in mTORC2 signaling because of the conditional deletion of the Rictor gene, iNKT cell numbers were reduced in the thymus and periphery. This is caused by decreased proliferation of stage 1 iNKT cells and poor development through subsequent stages. Functionally, iNKT cells devoid of mTORC2 signaling showed reduced number of IL-4-expressing cells, which correlated with a decrease in the transcription factor GATA-3-expressing cells. However, promyelocytic leukemia zinc-finger (PLZF), a critical transcription factor for iNKT cell development, is expressed at a similar level in mTORC2-deficient iNKT cells compared with that in the wild type iNKT cells. Furthermore, cellular localization of PLZF was not altered in the absence of mTOR2 signaling. Thus, our study reveals the PLZF-independent mechanisms of the development and function of iNKT cells regulated by mTORC2.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.