ArticleBMC genomics2014
Structure and decay of a proto-Y region in Tilapia, Oreochromis niloticus.
Article in BMC genomics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Characterization of the sex determining region and development of a molecular sex identification method in a Salangid fish.BMC genomics · 2024Article
- Absence ofInternational journal of molecular sciences · 2022Article
- Identification of sex chromosome and sex-determining gene of southern catfish (Proceedings. Biological sciences · 2022Article
- Polymorphism of Sex Determination Amongst Wild Populations Suggests its Rapid Turnover Within the Nile Tilapia Species.Frontiers in genetics · 2022Article
- Schistosome W-Linked Genes Inform Temporal Dynamics of Sex Chromosome Evolution and Suggest Candidate for Sex Determination.Molecular biology and evolution · 2021Article
- Origin of a Giant Sex Chromosome.Molecular biology and evolution · 2021Article
- A Chromosome-Level Genome Assembly of Mozambique Tilapia (Frontiers in genetics · 2021Article
- Disagreement in FMolecular ecology resources · 2020Article
- Structure and Sequence of the Sex Determining Locus in Two Wild Populations of Nile Tilapia.Genes · 2020Article
- Sex chromosome and sex locus characterization in goldfish, Carassius auratus (Linnaeus, 1758).BMC genomics · 2020Article
- Fine Mapping Using Whole-Genome Sequencing Confirms Anti-Müllerian Hormone as a Major Gene for Sex Determination in Farmed Nile Tilapia (G3 (Bethesda, Md.) · 2019Article
- Identification of the master sex determining gene in Northern pike (Esox lucius) reveals restricted sex chromosome differentiation.PLoS genetics · 2019Article
- Characterization of sex chromosomes in three deeply diverged species of Pseudocrenilabrinae (Teleostei: Cichlidae).Hydrobiologia · 2019Article
- Chromosome-scale assemblies reveal the structural evolution of African cichlid genomes.GigaScience · 2019Article
- Sex-Biased Gene Expression and Dosage Compensation on the Artemia franciscana Z-Chromosome.Genome biology and evolution · 2019Article
- Mismatches between the genetic and phenotypic sex in the wild Kou population of Nile tilapiaPeerJ · 2019Article
- Review
- Transcriptome display during tilapia sex determination and differentiation as revealed by RNA-Seq analysis.BMC genomics · 2018Article
- ddRADseq reveals determinants for temperature-dependent sex reversal in Nile tilapia on LG23.BMC genomics · 2017Article
- A high quality assembly of the Nile Tilapia (Oreochromis niloticus) genome reveals the structure of two sex determination regions.BMC genomics · 2017Article
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5 authors.
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Abstract
backgroundSex-determination genes drive the evolution of adjacent chromosomal regions. Sexually antagonistic selection favors the accumulation of inversions that reduce recombination in regions adjacent to the sex-determination gene. Once established, the clonal inheritance of sex-linked inversions leads to the accumulation of deleterious alleles, repetitive elements and a gradual decay of sex-linked genes. This in turn creates selective pressures for the evolution of mechanisms that compensate for the unequal dosage of gene expression. Here we use whole genome sequencing to characterize the structure of a young sex chromosome and quantify sex-specific gene expression in the developing gonad.
resultsWe found an 8.8 Mb block of strong differentiation between males and females that corresponds to the location of a previously mapped sex-determiner on linkage group 1 of Oreochromis niloticus. Putatively disruptive mutations are found in many of the genes within this region. We also found a significant female-bias in the expression of genes within the block of differentiation compared to those outside the block of differentiation. Eight candidate sex-determination genes were identified within this region.
conclusionsThis study demonstrates a block of differentiation on linkage group 1, suggestive of an 8.8 Mb inversion encompassing the sex-determining locus. The enrichment of female-biased gene expression inside the proposed inversion suggests incomplete dosage compensation. This study helps establish a model for studying the early-to-intermediate stages of sex chromosome evolution.
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