ArticleMolecular brain2014
Cdk5/p35 functions as a crucial regulator of spatial learning and memory.
Article in Molecular brain, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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25 citing papers in PubMed, 41 citations in OpenAlex.
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- Decoding brain memory formation by single-cell RNA sequencing.Briefings in bioinformatics · 2022Article
- Involvement of Cdk5 activating subunit p35 in synaptic plasticity in excitatory and inhibitory neurons.Molecular brain · 2022Article
- Long-Term Depression-Inducing Low Frequency Stimulation Enhances p-Tau181 and p-Tau217 in an Age-Dependent Manner in Live Rats.Journal of Alzheimer's disease : JAD · 2022Article
- Effect of θ–γ neural oscillation stimulation in hippocampal CA3 area on spatial cognition ability in ratsZhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2021Article
- Characterization of the plasma proteomic profile of frailty phenotype.GeroScience · 2021Article
- Role of Calpain-1 in Neurogenesis.Frontiers in molecular biosciences · 2021Article
- Nafamostat mesylate attenuates the pathophysiologic sequelae of neurovascular ischemia.Neural regeneration research · 2020Review
- Role of Cdk5 in Kalirin7-Mediated Formation of Dendritic Spines.Neurochemical research · 2019Article
- An Interstitial 17q11.2 de novo Deletion Involving theMolecular syndromology · 2019Article
- Inducible Knockout of the Cyclin-Dependent Kinase 5 Activator p35 Alters Hippocampal Spatial Coding and Neuronal Excitability.Frontiers in cellular neuroscience · 2018Article
- Hippocampal calpain is required for the consolidation and reconsolidation but not extinction of contextual fear memory.Molecular brain · 2017Article
- Nafamostat Mesilate Improves Neurological Outcome and Axonal Regeneration after Stroke in Rats.Molecular neurobiology · 2017Article
- CRMPs Function in Neurons and Glial Cells: Potential Therapeutic Targets for Neurodegenerative Diseases and CNS Injury.Molecular neurobiology · 2017Review
- Cyclin-dependent Kinase 5: Novel role of gene variants identified in ADHD.Scientific reports · 2017Article
- The transcription factor XBP1 in memory and cognition: Implications in Alzheimer disease.Molecular medicine (Cambridge, Mass.) · 2017Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCyclin-dependent kinase 5 (Cdk5), which is activated by binding to p35 or p39, is involved in synaptic plasticity and affects learning and memory formation. In Cdk5 knockout (KO) mice and p35 KO mice, brain development is severely impaired because neuronal migration is impaired and lamination is disrupted. To avoid these developmental confounders, we generated inducible CreER-p35 conditional (cKO) mice to study the role of Cdk5/p35 in higher brain function.
resultsCreER-p35 cKO mice exhibited spatial learning and memory impairments and reduced anxiety-like behavior. These phenotypes resulted from a decrease in the dendritic spine density of CA1 pyramidal neurons and defective long-term depression induction in the hippocampus.
conclusionsTaken together, our findings reveal that Cdk5/p35 regulates spatial learning and memory, implicating Cdk5/p35 as a therapeutic target in neurological disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.