ArticleBMC gastroenterology2014
The changing clinical profile of celiac disease: a 15-year experience (1998-2012) in an Italian referral center.
Article in BMC gastroenterology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 4 of them syntheses that pooled it.
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Who cites it
86 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Dermatitis Herpetiformis in Celiac Disease: A Systematic Review and Meta-Analysis.United European gastroenterology journal · 2026Pooled it
- The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a systematic review and meta-analysis.BMC gastroenterology · 2024Pooled it
- Effect of gluten-free diet on autoimmune thyroiditis progression in patients with no symptoms or histology of celiac disease: a meta-analysis.Frontiers in endocrinology · 2023Pooled it
- Prevalence of Celiac Disease in Patients With Turner Syndrome: Systematic Review and Meta-Analysis.Frontiers in medicine · 2021Pooled it
- Evaluation of the Impact of the COVID-19 Pandemic on the Clinical Presentation of Pediatric Celiac Disease.Pediatric gastroenterology, hepatology & nutrition · 2026Article
- Clinical and Histopathological Profile of Adults with Celiac Disease at Diagnosis and on a Gluten-Free Diet: A Cross-Sectional Observational Study.Clinics and practice · 2026Article
- Ocular Manifestations of Celiac Disease: Current Evidence and Clinical Implications.Nutrients · 2025Review
- Challenges in the Pediatric Celiac Disease Diagnosis: An Up-to-Date Review.Diagnostics (Basel, Switzerland) · 2025Review
- Diagnostic Challenges in Enteropathies: A Histopathological Review.Diagnostics (Basel, Switzerland) · 2025Review
- Unusual Location of a Rare Complication of Celiac Disease.GE Portuguese journal of gastroenterology · 2025Article
- Prevalence of Joint Complaints in Patients with Celiac Disease: A Systematic Review and Meta-Analysis.Journal of clinical medicine · 2025Review
- Dietary assessments in individuals living with coeliac disease: key considerations.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2025Review
- Associations of Clinical Presentation of Coeliac Disease with Comorbidities and Complications: A Retrospective Single-Centre Analysis.Journal of personalized medicine · 2025Article
- Gluten-Free Diet and Health-Related Quality of Life: The Validated Hellenic Version of the Celiac Dietary Adherence Test.Nutrients · 2025Article
- CLINICAL AND HISTOLOGICAL COMPARISON OF CELIAC DISEASE AND DERMATITIS HERPETIFORMIS IN MALE PATIENTS: A TEN-YEAR RETROSPECTIVE STUDY.Arquivos de gastroenterologia · 2025Article
- Psychometric Evaluation of the Celiac Disease Symptom Diary 2.1Patient related outcome measures · 2025Article
- Exploring the association between atrial fibrillation and celiac disease: a comprehensive review.Annals of medicine and surgery (2012) · 2024Review
- Advances in understanding and managing celiac disease: Pathophysiology and treatment strategies.World journal of gastroenterology · 2024Article
- Severe Liver Damage in an Obese Patient: Onset of Celiac Disease or Overlap Syndrome?Diagnostics (Basel, Switzerland) · 2024Article
- Article
26 more citing papers are in PubMed but not listed here.
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Abstract
backgroundCeliac disease is a multiform, challenging condition characterized by extremely variable features. Our goal was to define clinical, serological and histopathological findings in a large cohort of celiacs diagnosed in a single referral center.
methodsFrom January 1998 to December 2012, 770 patients (599 females, median age 36 years, range 18-78 years) were diagnosed as celiacs at St. Orsola-Malpighi Hospital (Bologna, Italy). The clinical phenotypes were classified as: 1) classical (malabsorption syndrome); 2) non-classical (extraintestinal and/or gastrointestinal symptoms other than diarrhea); 3) subclinical. Serology, duodenal histology, comorbidities, response to gluten-free diet and complications were evaluated.
resultsDisease onset was symptomatic in 610 patients (79%), while 160 celiacs showed a subclinical phenotype. In the symptomatic group the non-classical prevailed over the classical phenotype (66% vs 34%). Diarrhea was found in 27%, while other gastrointestinal manifestations were bloating (20%), aphthous stomatitis (18%), alternating bowel habit (15%), constipation (13%) and gastroesophageal reflux disease (12%). Extraintestinal manifestations included osteopenia/osteoporosis (52%), anemia (34%), cryptogenic hypertransaminasemia (29%) and recurrent miscarriages (12%). Positivity for IgA tissue transglutaminase antibodies was detected in 97%. Villous atrophy was found in 87%, while 13% had minor lesions consistent with potential celiac disease. A large proportion of patients showed autoimmune disorders, i.e. autoimmune thyroiditis (26.3%), dermatitis herpetiformis (4%) and diabetes mellitus type 1 (3%). Complicated celiac disease was very rare.
conclusionsOur study demonstrates that the clinical profile of celiac disease changed over time with an increasing rate of non-classical and subclinical phenotypes.
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