Evidence map›Paper›PMID 25404157›Full record

ArticleJournal of the American Society for Mass Spectrometry2015

Design of portable mass spectrometers with handheld probes: aspects of the sampling and miniature pumping systems.

Chien-Hsun Chen, Tsung-Chi Chen, Xiaoyu Zhou, Robert Kline-Schoder, Paul Sorensen, R Graham Cooks, Zheng Ouyang

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 69 citations in OpenAlex.

  1. Review
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  13. Quantitative mass spectrometry methods for pharmaceutical analysis.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2016
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Chien-Hsun ChenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN, 47907, USA.
Tsung-Chi Chen
Xiaoyu Zhou
Robert Kline-Schoder
Paul Sorensen
R Graham Cooks
Zheng Ouyang
Purdue University West Lafayette · USCreare (United States) · US

Funding

Development of a Point-of-Care Mass Spectrometry Analysis SystemR01GM106016 · NIGMS · PURDUE UNIVERSITY · PI OUYANG, ZHENG · 2013 to 2016
$1.1M
NIGMS NIH HHS 1R01GM106016NIGMS NIH HHS R01 GM106016
6 · The paper itself

Abstract

Miniature mass spectrometry analytical systems of backpack configuration fitted with sampling probes could potentially be of significant interest for in-field, real-time chemical analysis. In this study, various configurations were explored in which a long narrow tube was used to connect the turbo and backing pumps used to create and maintain vacuum. Also, for the first time we introduced two new types of pumps for miniature mass spectrometers, the Creare 130 g drag pump and Creare 350 g scroll backing pump. These pumps, along with another Creare 550 turbo pump and the commercially available Pfeiffer HiPace 10 turbo and KnF diaphragm backing pumps, were tested with the backpack configurations. The system performance, especially the scan time, was characterized when used with a discontinuous atmospheric pressure interface (DAPI) for ion introduction. The pumping performance in the pressure region above 1 mtorr is critical for DAPI operation. The 550 g turbo pump was shown to have a relatively higher pumping speed above 1 mtorr and gave a scan time of 300 ms, almost half the value obtained with the larger, heavier HiPace 10 often used with miniature mass spectrometers. The 350 g scroll pump was also found to be an improvement over the diaphragm pumps generally used as backing pumps. With a coaxial low temperature plasma ion source, direct analysis of low volatility compounds glass slides was demonstrated, including 1 ng DNP (2,4-Dinitrophenol) and 10 ng TNT (2,4,6-trinitrotoluene) with Creare 550 g turbo pump as well as 10 ng cocaine and 20 ng DNP with Creare 130 g drag pump.

Indexed as

2,4-DinitrophenolCocaineEquipment DesignExplosive AgentsMass SpectrometryMiniaturizationPressureSpecimen HandlingTrinitrotoluene2,4-DinitrophenolCocaineExplosive AgentsTrinitrotoluene

Identifiers

PMID25404157
PMCPMC4323736
OpenAlexW2148017550

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.