Evidence map›Paper›PMID 25404096›Full record

ReviewCurrent atherosclerosis reports2015

Recommendations for the management of patients with familial hypercholesterolemia.

David I Feldman, Michael J Blaha, Raul D Santos, Steve R Jones, Roger S Blumenthal, Peter P Toth, Laurence S Sperling, Seth S Martin

Open access · greenAbstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 5 institutions in 2 countries.

David I FeldmanJohns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA, Difeldman4@gmail.com.
Michael J Blaha
Raul D Santos
Steve R Jones
Roger S Blumenthal
Peter P Toth
Laurence S Sperling
Seth S Martin
Johns Hopkins Medicine · USJohns Hopkins University · USCGH Medical Center · USEmory University · USHospital São Paulo · BR

Funding

CARDIOVASCULAR EPIDEMIOLOGY INSTITUTIONAL TRAININGT32HL007024 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI Elizabeth Selvin · 1985 to 2026
$17.5M
NHLBI NIH HHS T32HL07024
6 · The paper itself

Abstract

Familial hypercholesterolemia (FH), characterized by congenitally elevated low-density lipoprotein cholesterol levels, is estimated to affect 20 million people worldwide. In patients with heterozygous FH, coronary artery disease manifests in about half of men by age 50 and one third of women by age 60, while homozygous FH patients often suffer coronary events in the first or second decade of life. Early diagnosis and aggressive treatment are paramount. However, many FH patients remain undiagnosed and/or inadequately treated. There is a considerable need for more effective screening and diagnosis of FH in the United States. Our objective herein is to provide concise overviews of how to screen for and diagnose FH and summarize international consensus recommendations for managing adults and children with available treatments.

Indexed as

Disease ManagementPractice Guidelines as TopicHumansHyperlipoproteinemia Type IILipoproteins, LDLLipoproteins, LDL

Identifiers

PMID25404096
OpenAlexW2048844198

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.