ArticlePsychopharmacology2015
Chronic administration of ketamine mimics the perturbed sense of body ownership associated with schizophrenia.
Article in Psychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed.
- Brain Networks, Neurotransmitters and Psychedelics: Towards a Neurochemistry of Self-Awareness.Current neurology and neuroscience reports · 2024Review
- Body transfer illusions in the schizophrenia spectrum: a systematic review.Schizophrenia (Heidelberg, Germany) · 2022Review
- Deficits in Sense of Body Ownership, Sensory Processing, and Temporal Perception in Schizophrenia Patients With/Without Auditory Verbal Hallucinations.Frontiers in neuroscience · 2022Article
- Mis-anaesthetized society: expectancies and recreational use of ketamine in Taiwan.BMC public health · 2019Article
- Autism and psychosis as diametrical disorders of embodiment.Evolution, medicine, and public health · 2019Article
- On the safety of repeated ketamine infusions for the treatment of depression: Effects of sex and developmental periods.Neurobiology of stress · 2018Review
- Explaining Delusions: Reducing Uncertainty Through Basic and Computational Neuroscience.Schizophrenia bulletin · 2017Review
- Prediction error, ketamine and psychosis: An updated model.Journal of psychopharmacology (Oxford, England) · 2016Review
- Widespread reductions in cortical thickness following ketamine abuse.Journal of psychiatry & neuroscience : JPNArticle
Corrections and comments
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Authors and funding
12 authors.
Funding
Abstract
rationaleSubanaesthetic ketamine infusion in healthy volunteers induces experiences redolent of early psychosis, including changes in the experience of one's own body. It is not clear, however, whether repeated self-administration of ketamine has a sustained effect on body representation that is comparable to that found during acute administration.
objectivesWe sought to establish whether chronic ketamine use resulted in disturbances to sense of body ownership.
methodsFollowing on from our work on the effects of acute ketamine infusion, we used the rubber hand illusion (RHI) to experimentally manipulate the sense of body ownership in chronic ketamine users, compared to healthy controls.
resultsChronic ketamine users experienced the RHI more strongly and reported more body-image aberrations, even though they had not recently taken the drug.
conclusionsThese findings suggest that the chronic ketamine model for psychosis models more long-lasting changes in sense of ownership, perhaps more akin to schizophrenia.
Indexed as
Identifiers
25404087What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.