ArticleThe American journal of tropical medicine and hygiene2015
Factors associated with mortality in febrile patients in a government referral hospital in the Kenema district of Sierra Leone.
Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clinical characterization of Lassa fever: A systematic review of clinical reports and research to inform clinical trial design.PLoS neglected tropical diseases · 2021Pooled it
- Monitoring Serious Adverse Events in the Sierra Leone Trial to Introduce a Vaccine Against Ebola.The Journal of infectious diseases · 2018Trial
- Lassa Fever Natural History and Clinical Management.Current topics in microbiology and immunology · 2023Article
- Beyond Lassa Fever: Systemic and structural barriers to disease detection and response in Sierra Leone.PLoS neglected tropical diseases · 2022Article
- Late diagnosis of Lassa fever outbreak in endemic areas lead to high mortality, Kenema District, Sierra Leone, February - March 2019.The Pan African medical journal · 2022Article
- A rapid research needs appraisal methodology to identify evidence gaps to inform clinical research priorities in response to outbreaks-results from the Lassa fever pilot.BMC medicine · 2019Article
- Surveillance of Vector-Borne Infections (Chikungunya, Dengue, and Malaria) in Bo, Sierra Leone, 2012-2013.The American journal of tropical medicine and hygiene · 2017Article
- Prevalence of Lassa Virus Disease (LVD) in Nigerian children with fever or fever and convulsions in an endemic area.PLoS neglected tropical diseases · 2017Article
- Derivation and validation of a universal vital assessment (UVA) score: a tool for predicting mortality in adult hospitalised patients in sub-Saharan Africa.BMJ global health · 2017Article
- Technical and Alarm signs for referral in adult patients with acute febrile illness: A study from a tertiary care hospital in North India.Journal of family medicine and primary careArticle
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6 authors.
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Abstract
There is a paucity of data on the etiologies and outcomes of febrile illness in rural Sierra Leone, especially in the Lassa-endemic district of Kenema. We conducted a retrospective study of patients with subjective or documented fever (T ≥ 38.0°C) who were admitted to a rural tertiary care hospital in Kenema between November 1, 2011 and October 31, 2012. Of 854 patients admitted during the study period, 429 (50.2%) patients had fever on admission. The most common diagnoses were malaria (27.3%), pneumonia (5.1%), and Lassa fever (4.9%). However, 53.4% of febrile patients had no diagnosis at discharge. The in-hospital mortality rate was 18.9% and associated with documented temperature ≥ 38.0°C (adjusted odds ratio [AOR] = 2.89, P = 0.001) and lack of diagnosis at discharge (AOR = 2.04, P = 0.03). Failure to diagnose the majority of febrile adults and its association with increased mortality highlight the need for improved diagnostic capacity to improve patient outcomes.
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