Trial reportPlant foods for human nutrition (Dordrecht, Netherlands)2014
Chia flour supplementation reduces blood pressure in hypertensive subjects.
Trial report in Plant foods for human nutrition (Dordrecht, Netherlands), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 104 citations in OpenAlex.
- Trial
- Lactobacilli-Fermented Chia Seeds as a Potential Anti-Hypertensive Agent.Molecules (Basel, Switzerland) · 2026Article
- Supplementation with Standardized Green/Black or White Tea Extracts Attenuates Hypertension and Ischemia-Reperfusion-Induced Myocardial Damage in Mice Infused with Angiotensin II.Antioxidants (Basel, Switzerland) · 2025Article
- Effects of chia seed (Salvia hispanica L.) supplementation on cardiometabolic health in overweight subjects: a systematic review and meta-analysis of RCTs.Nutrition & metabolism · 2024Review
- Consumption of a Byproduct of Chia Seed Oil Extraction by Cold Pressing Ameliorates Cardiovascular Risks Factors in an Experimental Model of Metabolically Unhealthy Normal Weight.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Article
- Chia (Molecules (Basel, Switzerland) · 2023Review
- Vasorelaxant Activity ofMolecules (Basel, Switzerland) · 2023Article
- Chia Oil and Mucilage Nanoemulsion: Potential Strategy to Protect a Functional Ingredient.International journal of molecular sciences · 2023Review
- Comparative Analysis of Metabolic Variations, Antioxidant Profiles and Antimicrobial Activity ofMolecules (Basel, Switzerland) · 2023Article
- Effects of Cold Pressed Chia Seed Oil Intake on Hematological and Biochemical Biomarkers in Both Normal and Hypercholesterolemic Rabbits.Plant foods for human nutrition (Dordrecht, Netherlands) · 2023Article
- Chia seeds (Food science & nutrition · 2023Review
- The Current State of Knowledge onMolecules (Basel, Switzerland) · 2022Review
- Practical applicability of genetics for the prevention and treatment of hypertension.Journal of clinical hypertension (Greenwich, Conn.) · 2022Article
- Arterial Hypertension-Oxidative Stress and Inflammation.Antioxidants (Basel, Switzerland) · 2022Review
- Article
- Chia Seeds (Molecules (Basel, Switzerland) · 2019Review
- Safety of chia seeds (EFSA journal. European Food Safety Authority · 2019Article
- Changes in Gut Microbiota Linked to a Reduction in Systolic Blood Pressure in Spontaneously Hypertensive Rats Fed an Extra Virgin Olive Oil-Enriched Diet.Plant foods for human nutrition (Dordrecht, Netherlands) · 2018Article
- Chia seed (Nutrition research and practice · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to investigate the effect of chia supplementation (Salvia hispanica L.) on blood pressure (BP) and its associated cardiometabolic factors in treated and untreated hypertensive individuals. The subjects were randomly assigned to one of the following groups: the hypertensive-drug treated (CHIA-MD, n = 10), hypertensive untreated (CHIA-NM, n = 9) and placebo (PLA-MD, n = 7) groups. The subjects consumed 35 g/day of either chia flour or a placebo for 12 weeks. The clinical and ambulatory BP, inflammation, oxidative stress and markers for nitric oxide were measured. While the PLA-MD group showed no changes in BP, there was a reduction in the mean clinical blood pressure (MBP) in the CHIA (111.5 ± 1.9 to 102.7 ± 1.5 mmHg, p < 0.001) and CHIA-MD (111.3 ± 2.2 to 100.1 ± 1.8 mmHg, p < 0.001) groups. The CHIA-NM group showed no reduction in the MBP but did show a decreased systolic BP (146.8 ± 3.8 to 137.3 ± 3.1 mmHg, p < 0.05). The clinical BP reduction was demonstrated by a 24 h ambulatory systolic reduction in all of the supplemented groups. However, the mean ambulatory BP was reduced only in the CHIA (98.1 ± 2.4 to 92.8 ± 2.2 mmHg, p < 0.05) group, and there was no change in the diastolic component in either of the CHIA groups. The lipid peroxidation was reduced in the CHIA (p = 0.04) and CHIA-NM (p = 0.02) groups compared with the PLA-MD group. A reduction in the plasma nitrite levels was observed only in the CHIA group (p = 0.02). Chia flour has the ability to reduce ambulatory and clinical BP in both treated and untreated hypertensive individuals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.