ArticleEvolution; international journal of organic evolution2015
Footprints of ancient-balanced polymorphisms in genetic variation data from closely related species.
Article in Evolution; international journal of organic evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- A cosmopolitan inversion facilitates seasonal adaptation in overwintering Drosophila.Genetics · 2024Pooled it
- What has population genomics told us about the dynamics of selection and plant adaptation?Molecular biology and evolution · 2026Review
- Overdominance for fitness: a genomic comparison between empirical and simulated data with Drosophila melanogaster.Genetics · 2026Article
- Trans-Specific Polymorphisms Between Cryptic Daphnia Species Affect Fitness and Behavior.Molecular ecology · 2025Article
- Population Genomic Scans for Natural Selection and Demography.Annual review of genetics · 2024Review
- Admixture in the fungal pathogen Blastomyces.Genetics · 2024Article
- Long-term balancing selection for pathogen resistance maintains trans-species polymorphisms in a planktonic crustacean.Nature communications · 2024Article
- Balancing selection and the functional effects of shared polymorphism in crypticbioRxiv : the preprint server for biology · 2024Article
- Balancing selection on an MYB transcription factor maintains the twig trichome color variation in Melastoma normale.BMC biology · 2023Article
- Inferring Balancing Selection From Genome-Scale Data.Genome biology and evolution · 2023Review
- The roles of balancing selection and recombination in the evolution of rattlesnake venom.Nature ecology & evolution · 2022Article
- A new test suggests hundreds of amino acid polymorphisms in humans are subject to balancing selection.PLoS biology · 2022Article
- Diverse functions associate with non-coding polymorphisms shared between humans and chimpanzees.BMC ecology and evolution · 2022Article
- A shift to shorter cuticular hydrocarbons accompanies sexual isolation amongEvolution letters · 2021Article
- A balancing act between primate lentiviruses and their receptor.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Host-parasite co-evolution and its genomic signature.Nature reviews. Genetics · 2020Review
- Flexible Mixture Model Approaches That Accommodate Footprint Size Variability for Robust Detection of Balancing Selection.Molecular biology and evolution · 2020Article
- Human adaptation over the past 40,000 years.Current opinion in genetics & development · 2020Review
- Antimicrobial peptides: Application informed by evolution.Science (New York, N.Y.) · 2020Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
When long-lasting, balancing selection can lead to "trans-species" polymorphisms that are shared by two or more species identical by descent. In such cases, the gene genealogy at the selected site clusters by allele instead of by species, and nearby neutral sites also have unusual genealogies because of linkage. While this scenario is expected to leave discernible footprints in genetic variation data, the specific patterns remain poorly characterized. Motivated by recent findings in primates, we focus on the case of a biallelic polymorphism under ancient balancing selection and derive approximations for summaries of the polymorphism data from two species. Specifically, we characterize the length of the segment that carries most of the footprints, the expected number of shared neutral single nucleotide polymorphisms (SNPs), and the patterns of allelic associations among them. We confirm the accuracy of our approximations by coalescent simulations. We further show that for humans and chimpanzees-more generally, for pairs of species with low genetic diversity levels-these patterns are highly unlikely to be generated by neutral recurrent mutations. We discuss the implications for the design and interpretation of genome scans for ancient balanced polymorphisms in primates and other taxa.
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