Evidence map›Paper›PMID 25403745›Full record

ArticleBrain topography2015

Ultra-rapid access to words in chronic aphasia: the effects of intensive language action therapy (ILAT).

Lucy J MacGregor, Stephanie Difrancesco, Friedemann Pulvermüller, Yury Shtyrov, Bettina Mohr

Registry-linked trialOpen access · hybridAbstract read
In one paragraph

Article in Brain topography, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02928822 (Terapia de Lenguaje, Sensorial y Motora, Basada en Realidad Virtual), which is not on this map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02928822 nacompletednot on this mapstarted 2016, after this paper: background citation

Terapia de Lenguaje, Sensorial y Motora, Basada en Realidad Virtual

TypeinterventionalSponsorUniversitat Pompeu FabraRan2016 to 2018Enrolled18ConditionsBroca's AphasiaArmsVR-based sensorimotor aphasia therapy, Control Group (conventional aphasia rehabilitation)
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Article
  3. Is Aphasia Treatment Beneficial for the Elderly? A Review of Recent Evidence.Current physical medicine and rehabilitation reports · 2020
    Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 5 institutions in 4 countries.

Lucy J MacGregorMedical Research Council, Cognition and Brain Sciences Unit, 15 Chaucer Road, Cambridge, CB2 7EF, UK, lucy.macgregor@mrc-cbu.cam.ac.uk.
Stephanie Difrancesco
Friedemann Pulvermüller
Yury Shtyrov
Bettina Mohr
Aarhus University · DKAnglia Ruskin University · GBCharité - Universitätsmedizin Berlin · DEFreie Universität Berlin · DEMRC Cognition and Brain Sciences Unit · GB

Funding

Medical Research Council MC_A060_5PQ90Medical Research Council MC_U105580445Medical Research Council MC_U105597122Medical Research Council MC_US_A060_0043Medical Research Council MR/K005464/1
6 · The paper itself

Abstract

Effects of intensive language action therapy (ILAT) on automatic language processing were assessed using Magnetoencephalography (MEG). Auditory magnetic mismatch negativity (MMNm) responses to words and pseudowords were recorded in twelve patients with chronic aphasia before and immediately after two weeks of ILAT. Following therapy, Patients showed significant clinical improvements of auditory comprehension as measured by the Token Test and in word retrieval and naming as measured by the Boston Naming Test. Neuromagnetic responses dissociated between meaningful words and meaningless word-like stimuli ultra-rapidly, approximately 50 ms after acoustic information first allowed for stimulus identification. Over treatment, there was a significant increase in the left-lateralisation of this early word-elicited activation, observed in perilesional fronto-temporal regions. No comparable change was seen for pseudowords. The results may reflect successful, therapy-induced, language restitution in the left hemisphere.

Indexed as

Acoustic StimulationAdultAgedAphasiaBrainChronic DiseaseFemaleHumansLanguage TestsLanguage TherapyMagnetoencephalographyMaleMiddle AgedSpeech Perception

Identifiers

PMID25403745
PMCPMC4330459
OpenAlexW2065775817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.