ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Disrupted functional and structural networks in cognitively normal elderly subjects with the APOE ɛ4 allele.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 1 of them a synthesis that pooled it.
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Who cites it
37 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- Imaging Alzheimer's genetic risk using diffusion MRI: A systematic review.NeuroImage. Clinical · 2020Pooled it
- Review
- Disrupted theta oscillation propagation in healthy elderly individuals with apolipoprotein E epsilon 4 allele.Frontiers in neuroscience · 2025Article
- Sex differences in interacting genetic and functional connectivity biomarkers in Alzheimer's disease.GeroScience · 2024Article
- Brain network fingerprints of Alzheimer's disease risk factors in mouse models with humanized APOE alleles.Magnetic resonance imaging · 2024Article
- The brain network hub degeneration in Alzheimer's disease.Biophysics reports · 2024Article
- APOE, Immune Factors, Sex, and Diet Interact to Shape Brain Networks in Mouse Models of Aging.bioRxiv : the preprint server for biology · 2024Article
- Leisure activities as reserve mediators of the relationship between loneliness and cognition in aging.Translational psychiatry · 2024Article
- Hippocampal connectivity and memory decline in cognitively intact APOE ε4 carriers.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
- Functional and structural network changes related with cognition in semantic dementia longitudinally.Human brain mapping · 2023Article
- Genotypic effects of APOE-ε4 on resting-state connectivity in cognitively intact individuals support functional brain compensation.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Environmental effects on brain functional networks in a juvenile twin population.Scientific reports · 2023Article
- Differences in resting-state brain networks and gray matter between APOE ε2 and APOE ε4 carriers in non-dementia elderly.Frontiers in psychiatry · 2023Article
- Dyslipidemia induced large-scale network connectivity abnormality facilitates cognitive decline in the Alzheimer's disease.Journal of translational medicine · 2022Article
- Impact ofFrontiers in aging neuroscience · 2022Article
- Classification of type 2 diabetes mellitus with or without cognitive impairment from healthy controls using high-order functional connectivity.Human brain mapping · 2021Article
- Small-World Networks and Their Relationship With Hippocampal Glutamine/Glutamate Concentration in Healthy Adults With Varying Genetic Risk for Alzheimer's Disease.Journal of magnetic resonance imaging : JMRI · 2021Article
- The human connectome in Alzheimer disease - relationship to biomarkers and genetics.Nature reviews. Neurology · 2021Review
- Relating Global and Local Connectome Changes to Dementia and Targeted Gene Expression in Alzheimer's Disease.Frontiers in human neuroscience · 2021Article
- Learning Common Harmonic Waves on Stiefel Manifold - A New Mathematical Approach for Brain Network Analyses.IEEE transactions on medical imaging · 2021Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
As the Apolipoprotein E (APOE) ɛ4 allele is a major genetic risk factor for sporadic Alzheimer's disease (AD), which has been suggested as a disconnection syndrome manifested by the disruption of white matter (WM) integrity and functional connectivity (FC), elucidating the subtle brain structural and functional network changes in cognitively normal ɛ4 carriers is essential for identifying sensitive neuroimaging based biomarkers and understanding the preclinical AD-related abnormality development. We first constructed functional network on the basis of resting-state functional magnetic resonance imaging and a structural network on the basis of diffusion tensor image. Using global, local and nodal efficiencies of these two networks, we then examined (i) the differences of functional and WM structural network between cognitively normal ɛ4 carriers and non-carriers simultaneously, (ii) the sensitivity of these indices as biomarkers, and (iii) their relationship to behavior measurements, as well as to cholesterol level. For ɛ4 carriers, we found reduced global efficiency significantly in WM and marginally in FC, regional FC dysfunctions mainly in medial temporal areas, and more widespread for WM network. Importantly, the right parahippocampal gyrus (PHG.R) was the only region with simultaneous functional and structural damage, and the nodal efficiency of PHG.R in WM network mediates the APOE ɛ4 effect on memory function. Finally, the cholesterol level correlated with WM network differently than with the functional network in ɛ4 carriers. Our results demonstrated ɛ4-specific abnormal structural and functional patterns, which may potentially serve as biomarkers for early detection before the onset of the disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.