ArticleForensic science, medicine, and pathology2015
An update on oxycodone: lessons for death investigators in Australia.
Article in Forensic science, medicine, and pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Opioid use and misuse in children, adolescents, and young adults with cancer: a systematic review of the literature.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Pooled it
- Review
- Reducing opioid use for chronic non-cancer pain in primary care using an evidence-based, theory-informed, multistrategic, multistakeholder approach: a single-arm time series with segmented regression.BMJ quality & safety · 2023Article
- Evaluation of a post-discharge pharmacist opioid review following total knee arthroplasty: a pre- and post-intervention cohort study.International journal of clinical pharmacy · 2022Article
- Opioid prescribing in general practice: an Australian cross-sectional survey.BMC primary care · 2022Article
- Oxycodone-Related Deaths: The Significance of Pharmacokinetic and Pharmacodynamic Drug Interactions.European journal of drug metabolism and pharmacokinetics · 2022Article
- Disease Burden and Costs in Moderate-to-Severe Chronic Osteoarthritis Pain Refractory to Standard of Care: Ancillary Analysis of the OPIOIDS Real-World Study.Rheumatology and therapy · 2021Article
- Future projections of opioid use and cost in patients with chronic osteoarthritis pain in Spain.Therapeutic advances in musculoskeletal disease · 2021Article
- Adverse drug reactions due to opioid analgesic use in New South Wales, Australia: a spatial-temporal analysis.BMC pharmacology & toxicology · 2019Article
- Updated Clinical Pharmacokinetics and Pharmacodynamics of Oxycodone.Clinical pharmacokinetics · 2019Review
- Persistence with opioids post discharge from hospitalisation for surgery in Australian adults: a retrospective cohort study.BMJ open · 2019Article
- Prevalence and incidence of prescription opioid analgesic use in Australia.British journal of clinical pharmacology · 2019Article
- Predictors of persistent prescription opioid analgesic use among people without cancer in Australia.British journal of clinical pharmacology · 2018Article
- Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic.Frontiers in psychiatry · 2018Review
- Exploring coronial determination of intent for poisoning-related deaths in Australia, 2001-2013.BMC public health · 2017Article
- Initiation of strong prescription opioids in Australia: cohort characteristics and factors associated with the type of opioid initiated.British journal of clinical pharmacology · 2016Observational
- Dealing with drug-seeking behaviour.Australian prescriber · 2016Review
- Drug diversion.Australian prescriber · 2015Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxycodone is one of the most abused prescription drugs. Iatrogenic factors that lead to oxycodone-related death, such as mis-prescribing, present an opportunity for death prevention if identified early. This study investigated deaths involving oxycodone in Australia to explore potentially inappropriate prescribing and the coroner's investigation. The National Coronial Information System identified cases from 2001 to 2011 where oxycodone was detected by toxicological analysis. There were 806 oxycodone-related deaths, with a significant increase in the 11-year period, from 21 deaths in 2001, up almost sevenfold in 2011 (139 deaths). Most deaths were caused by combined drug toxicity (63.4%) or oxycodone toxicity alone (11.8%). Most individuals were male (59.1%), aged 35-44 years (26.7%), who died unintentionally (56.4%), with mental illness (52.1%) and/or a history of acute or chronic pain (46.2%). 312 cases (39%) described a legitimate prescription for oxycodone, of which most involved non-cancer related chronic pain. About three quarters of the indications were deemed appropriate. There were at least 43 different indications treated with oxycodone that were inappropriate. The majority of oxycodone-related cases involved minor to no description of the drugs involved (n = 600; 74.4%). A moderate description of oxycodone involvement was given in 162 cases (20.1%), while only 44 cases (5.5%) involved a thorough examination and recommendations from the coroners on oxycodone and other drugs involved in death. This study emphasized the need for medical practitioners to exercise caution when prescribing oxycodone and for coroners to provide more consistent and detailed information regarding drug use, in order to identify and implement preventive strategies.
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