Observational studyBMC infectious diseases2014
Quality of life and wellbeing among HIV outpatients in East Africa: a multicentre observational study.
Observational study in BMC infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Mental health and well-being of older adults living with HIV in sub-Saharan Africa: a systematic review.BMJ open · 2021Pooled it
- Active ingredients of a person-centred intervention for people on HIV treatment: analysis of mixed methods trial data.BMC infectious diseases · 2018Trial
- The impact of antiretroviral therapy on symptom burden among HIV outpatients with low CD4 count in rural Uganda: nested longitudinal cohort study.BMC palliative care · 2017Trial
- Impact of differentiated service delivery models on quality of life among people living with HIV in Uganda- a quasi-experimental study.AIDS research and therapy · 2025Article
- Health-related quality of life and associated factors among people living with HIV/AIDS in Lagos, Nigeria.African journal of primary health care & family medicine · 2024Article
- Health-related quality of life of patients with HIV/AIDS at a tertiary care teaching hospital in Ethiopia.Health and quality of life outcomes · 2021Article
- Does sexual behaviour of people with HIV reflect antiretroviral therapy as a preventive strategy? A cross-sectional study among outpatients in Kenya.BMC public health · 2019Article
- Change in multidimensional problems and quality of life over three months after HIV diagnosis: a multicentre longitudinal study in Kenya and Uganda.BMC infectious diseases · 2019Article
- Relationship between CD4 count and quality of life over time among HIV patients in Uganda: a cohort study.Health and quality of life outcomes · 2015Article
- Integrating HIV and palliative care: ending the false dichotomy.The lancet. HIV · 2015Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
backgroundGlobal health investment has reduced HIV mortality and transmission. However, little is known of patient-reported outcomes alongside ART rollout. This study aimed to measure wellbeing using patient-reported outcome measures (PROMS) among outpatients at PEPFAR-funded facilities.
methodsIn a multicentre 2 country cross-sectional study, adults attending 12 facilities in Kenya and Uganda gave self-reported data on quality of life (physical and mental wellbeing dimensions), functional and a measure of multidimensional problems (physical, psychological, social and spiritual).
resultsAmong the 1,337 participants, multidimensional problems were more common in psychological, spiritual and social domains than in physical. In multivariable analysis using GEE to adjust for facility effect, the mental health subscale of quality of life was lower for people with limited functional status (B = -5.27, 95% CI -5.99, 1. -4.56 p < 0.001) and higher for wealthier people (B = 0.91, 95% CI 0.48, 1.33, p < 0.001). The physical health subscale of quality of life was lower for those with limited functional status (B = -8.58, 95% CI -9.46 to -7.70, p < 0.001) and those who had a caregiver present (B = -1.97, 95% CI -3.72 to -0.23, p = 0.027), higher for wealthier people (B = 1.14, 95% CI 0.65, 1.64, p < 0.001), and positively associated with CD4 count (B = 1.61, 95% CI 1.08-2.14, p < 0.001). Multidimensional problems were more burdensome for people with limited functional status (B = -2.06, 95% CI -2.46 to -1.66, p < 0.001), and less burdensome with more education (B = 0.63, 95% CI 0.25-1.00, p = 0.001) or ART use (B = 0.94, 95% CI 0.34-1.53, p = 0.002).
conclusionsMultidimensional problems are highly prevalent, and worse with declining function. Importantly, ART use does not appear to be protective for self-reported physical and mental dimensions of quality of life. Assessment and management of self-reported wellbeing must form part of HIV care and treatment services to ensure maximum benefit from ART investment.
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