ArticleClinical rheumatology2015
Basophil count, a marker for disease activity in systemic lupus erythematosus.
Article in Clinical rheumatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 23 citations in OpenAlex.
- Persistent cutaneous lupus erythematosus: A pathway toward systemic disease?Journal of translational autoimmunity · 2026Review
- Identification of Biomarkers Co-Associated with Lactylation and Acetylation in Systemic Lupus Erythematosus.Biomedicines · 2025Article
- TEMR: Trans-ethnic mendelian randomization method using large-scale GWAS summary datasets.American journal of human genetics · 2025Article
- Diacron-Reactive Oxygen Metabolites Levels Are Initially Elevated in Patients with Bullous Pemphigoid.JID innovations : skin science from molecules to population health · 2024Article
- PD-L1- and IL-4-expressing basophils promote pathogenic accumulation of T follicular helper cells in lupus.Nature communications · 2024Article
- Deep learning model to predict lupus nephritis renal flare based on dynamic multivariable time-series data.BMJ open · 2024Article
- The ratio of neutrophil to lymphocyte as a potential marker of clinicopathological activity for lupus nephritis.International urology and nephrology · 2024Article
- Double-Negative T (DNT) Cells in Patients with Systemic Lupus Erythematosus.Biomedicines · 2024Review
- CSL362 potently and specifically depletes pDCsiScience · 2023Article
- High serum immunoglobulin D levels in systemic lupus erythematosus: more to be found?Clinical rheumatology · 2023Article
- Higher basophil count decreases narcolepsy risk: a Mendelian randomization study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Article
- Analysis of Peripheral Blood Basophils in Pediatric Systemic Lupus Erythematosus.Diagnostics (Basel, Switzerland) · 2022Article
- Behind the scenes with basophils: an emerging therapeutic target.Immunotherapy advances · 2021Review
- Review
- Innate Immune Cells' Contribution to Systemic Lupus Erythematosus.Frontiers in immunology · 2019Review
- Low level of circulating basophil counts in biopsy-proven active lupus nephritis.Clinical rheumatology · 2018Article
- Aged mice display altered numbers and phenotype of basophils, and bone marrow-derived basophil activation, with a limited role for aging-associated microbiota.Immunity & ageing : I & A · 2018Article
- Association of calreticulin expression with disease activity and organ damage in systemic lupus erythematosus patients.Experimental and therapeutic medicine · 2017Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Systemic lupus erythematosus (SLE) is a chronic multisystem autoimmune disease, with frequent flares amid remissions. Basophils contribute to the immunopathogenesis of SLE. This retrospective clinical study evaluated blood basophil count as a potential marker of SLE activity. This study included 213 patients with SLE, 70 with non-SLE chronic kidney disease (CKD), and 100 healthy volunteers. SLE disease activity was scored using the SLE Disease Activity Index (SLEDAI). Baseline and post-immunosuppressant bioparameters were compared in patients with active SLE, with second samples taken at total SLEDAI ≤4. Blood basophil counts and other conventional biomarkers were compared among the groups. Among the 213 SLE patients (192 women, 21 men; mean age 33.0 ± 12.0 years), 149 had active disease. Basophil counts were significantly lower in patients with SLE than in patients with non-SLE CKD and healthy controls (0.009 ± 0.010 vs. 0.025 ± 0.015 vs. 0.022 ± 0.010 × 10(9)/L, p <0.001), and lower in patients with active than inactive SLE (0.008 ± 0.009 vs. 0.014 ± 0.012 × 10(9)/L, p <0.001). Basophil counts in SLE patients were significantly higher after than before immunosuppressive treatment (0.021 ± 0.017 vs. 0.008 ± 0.008 × 10(9)/L, p <0.001) and correlated with total SLEDAI score (r = -0.30, p <0.001). Receiver operator curve analysis showed that basophil counts were similar to conventional markers (leukocytes, platelets, and double-stranded (ds) DNA IgG) in differentiating active from inactive SLE. These findings indicate that blood basophil counts may be a useful biomarker in evaluating SLE activity.
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