ArticleeLife2014
Reinstatement of long-term memory following erasure of its behavioral and synaptic expression in Aplysia.
Article in eLife, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 66 papers.
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Who cites it
66 citing papers in PubMed, 151 citations in OpenAlex.
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- If Engrams Are the Answer, What Is the Question?Advances in neurobiology · 2024Article
- DNA Methylation Inhibition Reversibly Impairs the Long-Term Context Memory Maintenance inInternational journal of molecular sciences · 2023Article
- Engram neurons: Encoding, consolidation, retrieval, and forgetting of memory.Molecular psychiatry · 2023Review
- A computational passage-of-time model of the cerebellar Purkinje cell in eyeblink conditioning.Frontiers in computational neuroscience · 2023Article
- An evidence-based critical review of the mind-brain identity theory.Frontiers in psychology · 2023Article
- Learning in Transcriptional Network Models: Computational Discovery of Pathway-Level Memory and Effective Interventions.International journal of molecular sciences · 2022Article
- Precise timing of ERK phosphorylation/dephosphorylation determines the outcome of trial repetition during long-term memory formation.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Understanding the physical basis of memory: Molecular mechanisms of the engram.The Journal of biological chemistry · 2022Review
- Fruit Peels: Food Waste as a Valuable Source of Bioactive Natural Products for Drug Discovery.Current issues in molecular biology · 2022Review
- Forgetting as a form of adaptive engram cell plasticity.Nature reviews. Neuroscience · 2022Review
- The Role of DNA Methylation and Activity of Neurotransmitter Receptors in the Mechanisms of Specific Anterograde Amnesia and Memory Recovery.Bulletin of experimental biology and medicine · 2022Article
- Technological Approach to Mind Everywhere: An Experimentally-Grounded Framework for Understanding Diverse Bodies and Minds.Frontiers in systems neuroscience · 2022Article
- Excitatory postsynaptic calcium transients atLearning & memory (Cold Spring Harbor, N.Y.) · 2021Article
- Quantitative description of the interactions among kinase cascades underlying long-term plasticity of Aplysia sensory neurons.Scientific reports · 2021Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Long-term memory (LTM) is believed to be stored in the brain as changes in synaptic connections. Here, we show that LTM storage and synaptic change can be dissociated. Cocultures of Aplysia sensory and motor neurons were trained with spaced pulses of serotonin, which induces long-term facilitation. Serotonin (5HT) triggered growth of new presynaptic varicosities, a synaptic mechanism of long-term sensitization. Following 5HT training, two antimnemonic treatments-reconsolidation blockade and inhibition of PKM--caused the number of presynaptic varicosities to revert to the original, pretraining value. Surprisingly, the final synaptic structure was not achieved by targeted retraction of the 5HT-induced varicosities but, rather, by an apparently arbitrary retraction of both 5HT-induced and original synapses. In addition, we find evidence that the LTM for sensitization persists covertly after its apparent elimination by the same antimnemonic treatments that erase learning-related synaptic growth. These results challenge the idea that stable synapses store long-term memories.
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