ArticleNature chemical biology2015
Lipid-linked cell wall precursors regulate membrane association of bacterial actin MreB.
Article in Nature chemical biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 79 citations in OpenAlex.
- Polar growth factor PgfA regulates polar peptidoglycan synthesis as well as mycolate synthesis inJournal of bacteriology · 2026Article
- Wall teichoic acids regulate peptidoglycan synthesis to maintain rod shape in Bacillus subtilis.Nature microbiology · 2026Article
- Wall teichoic acids plug nanopores in Bacillus subtilis cell wall and regulate peptidoglycan synthesis.Nature microbiology · 2026Article
- A platinum butterfly effect: small changes turn an anticancer drug into a non-toxic metalloantibiotic with in vivo efficacy.npj antimicrobials and resistance · 2026Article
- Synergistic action of peptidoglycan and teichoic acid synthesis inhibitors leads to cell death by oxidative damage.Communications biology · 2026Article
- Contribution of theMicrobiology spectrum · 2026Article
- MreB filaments in the elongasome modulate E. coli membrane curvature.Biophysical journal · 2025Article
- Review
- Reducing Peptidoglycan Crosslinking by Chemical Modulator Reverts β-lactam Resistance in Methicillin-Resistant Staphylococcus aureus.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Article
- Visualization of Wall Teichoic Acid Decoration in Bacillus subtilis.Journal of bacteriology · 2023Article
- Plasma Membrane-Cell Wall Feedback in Bacteria.Journal of bacteriology · 2023Review
- Growth rate is modulated by monitoring cell wall precursors in Bacillus subtilis.Nature microbiology · 2023Article
- Combating Escherichia coli O157:H7 with Functionalized Chickpea-Derived Antimicrobial Peptides.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023Article
- Dissecting the roles of peptidoglycan synthetic and autolytic activities in the walled to L-form bacterial transition.Frontiers in microbiology · 2023Article
- Revisiting the Role of VraTSR inJournal of bacteriology · 2022Article
- Localized Production of Cell Wall Precursors May Be Critical for Regulating the Mycobacterial Cell Wall.Journal of bacteriology · 2022Article
- Mechanistic insights into the CChemical science · 2022Article
- Magnesium rescues the morphology of Bacillus subtilis mreB mutants through its inhibitory effect on peptidoglycan hydrolases.Scientific reports · 2022Article
- Resource sharing between central metabolism and cell envelope synthesis.Current opinion in microbiology · 2021Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The bacterial actin homolog MreB, which is crucial for rod shape determination, forms filaments that rotate around the cell width on the inner surface of the cytoplasmic membrane. What determines filament association with the membranes or with other cell wall elongation proteins is not known. Using specific chemical and genetic perturbations while following MreB filament motion, we find that MreB membrane association is an actively regulated process that depends on the presence of lipid-linked peptidoglycan precursors. When precursors are depleted, MreB filaments disassemble into the cytoplasm, and peptidoglycan synthesis becomes disorganized. In cells that lack wall teichoic acids but continue to make peptidoglycan, dynamic MreB filaments are observed, although their presence is not sufficient to establish a rod shape. We propose that the cell regulates MreB filament association with the membrane, allowing rapid and reversible inactivation of cell wall enzyme complexes in response to the inhibition of cell wall synthesis.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.