Evidence map›Paper›PMID 25402504›Full record

SynthesisPloS one2014

Evaluation of the quality of guidelines for myasthenia gravis with the AGREE II instrument.

Zhenchang Zhang, Jia Guo, Gang Su, Jiong Li, Hua Wu, Xiaodong Xie

Abstract readMeta-Analysis
In one paragraph

Synthesis in PloS one, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zhenchang ZhangSchool of Basic Medical Sciences, Lanzhou University, Lanzhou, P. R. China; Department of Neurology, The Second Hospital of Lanzhou University, Lanzhou, P. R. China.
Jia GuoDepartment of Neurology, The Second Hospital of Lanzhou University, Lanzhou, P. R. China.
Gang SuSchool of Basic Medical Sciences, Lanzhou University, Lanzhou, P. R. China.
Jiong LiSchool of Basic Medical Sciences, Lanzhou University, Lanzhou, P. R. China.
Hua WuDepartment of Neurology, The Second Hospital of Lanzhou University, Lanzhou, P. R. China.
Xiaodong XieSchool of Basic Medical Sciences, Lanzhou University, Lanzhou, P. R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundClinical practice guidelines (CPGs) are systematically developed statements to assist practitioners in making decisions about appropriate healthcare in specific clinical circumstances. The methodological quality of CPGs for myasthenia gravis (MG) are unclear.

objectiveTo critically evaluate the methodological quality of CPGs for MG using AGREE II instrument.

methodA systematical search strategy on PubMed, EMBASE, DynaMed, the National Guideline Clearinghouse (NGC) and the Chinese Biomedical Literature database (CBM) was performed on September 20th 2013. All guidelines related to MG were evaluated with AGREE II. The software used for analysis was SPSS 17.0.

resultsA total of 15 CPGs for MG met the inclusion criteria (12 CPGs in English, 3 CPGs in Chinese). The overall agreement among reviews was moderate or high (ICC >0.70). The mean scores (mean ± SD) for al six domains were presented as follows: scope and purpose (60.93% ± 16.62%), stakeholder involvement (40.93% ± 20.04%), rigor of development (37.22% ± 30.46%), clarity of presentation (64.26% ± 16.36%), applicability (28.19% ± 20.56%) and editorial independence (27.78% ± 28.28%). Compared with non-evidence-based CPGs, evidence-based CPGs had statistically significant higher quality scores for all AGREE II domains (P<0.05). All domain scores appear slightly higher for CPGs published after AGREE II instrument development and validation (P>0.05). The quality scores of CPGs developed by NGC/AAN were higher than the quality scores of CPGs developed by other organizations for all domains. The difference was statistically significant for all domains with the exception of clarity of presentation (P = 0.07).

conclusionsThe qualities of CPGs on MG were generally acceptable with several flaws. The AGREE II instrument should be adopted by guideline developers, particularly in China.

Indexed as

Practice Guidelines as TopicQuality of Health CareHumansMyasthenia Gravis

Identifiers

PMID25402504
PMCPMC4234220

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.