ArticleThe Journal of clinical investigation1989
Occupancy of platelet receptors for platelet-activating factor in patients with septicemia.
Article in The Journal of clinical investigation, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 104 citations in OpenAlex.
- Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage.The Journal of biological chemistry · 2014Article
- The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses.Biochimie · 2010Review
- Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates.Blood · 2009Article
- Amicus or adversary: platelets in lung biology, acute injury, and inflammation.American journal of respiratory cell and molecular biology · 2009Review
- Epistaxis as the initial manifestation of brucellosis.International journal of health sciences · 2008Article
- Efficacy and Safety of the Platelet-Activating Factor Receptor Antagonist BN 52021 (Ginkgolide B) in Patients with Severe Sepsis : A Randomised, Double-Blind, Placebo-Controlled, Multicentre Trial.Clinical drug investigation · 2004Article
- Cardiac dysfunction in sepsis: new theories and clinical implications.Intensive care medicine · 1998Review
- Modulatory effect of interleukin-10 on the production of platelet-activating factor and superoxide anions by human leucocytes.Immunology · 1997Article
- Role for intracellular platelet-activating factor in the circulatory failure in a model of gram-positive shock.British journal of pharmacology · 1995Article
- Are soluble factors relevant for polymorphonuclear leukocyte dysregulation in septicemia?Clinical and diagnostic laboratory immunology · 1995Article
- Platelet-activating factor and phospholipase A2 in patients with septic shock and trauma.Intensive care medicine · 1994Article
- Platelet-activating factor: receptors and signal transduction.The Biochemical journal · 1993Review
- Bacteria induce release of platelet-activating factor (PAF) from polymorphonuclear neutrophil granulocytes: possible role for PAF in pathogenesis of experimentally induced bacterial pneumonia.Infection and immunity · 1993Article
- The role of platelet-activating factor and peptidoleukotrienes in the vascular changes of rat passive anaphylaxis.British journal of pharmacology · 1992Article
- Platelet-activating factor type activity in plasma from patients with septicemia and other diseases.Lipids · 1991Article
- Review
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The possible involvement of platelet-activating factor (PAF) in the pathogenesis of endotoxemia, was investigated by using a binding assay to patients' platelets, complemented with the extraction and chemical characterization of PAF obtained from patients' platelets. Platelets from 12 human volunteers had 281 +/- 63 freely accessible high affinity binding sites (PAF-receptors) per platelet; whereas this number was of 49 +/- 37 PAF-receptors per platelet, n = 14 samples, P less than 0.01, in a group of 13 patients with positive blood culture. A group of patients with respiratory or cardiovascular disturbances and negative blood culture had 253 +/- 74, accessible receptors per platelet (n = 19 samples from 16 patients, P less than 0.01 as compared to septic patients, which was not significantly different when compared to control individuals). Patients with sepsis possessed significant amounts of PAF associated to their platelets, whereas this mediator could not be isolated from platelets of patients with respiratory or cardiovascular disturbances and negative blood culture, nor from platelets of control individuals. PAF was also assayed in whole blood samples and found at high concentrations in sepsis patients. These data indicate that occupancy of PAF receptors in combination with high amounts of platelet-associated PAF, is a common finding in patients with sepsis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.