ArticleACS nano2014
In situ fabrication of 3D Ag@ZnO nanostructures for microfluidic surface-enhanced Raman scattering systems.
Article in ACS nano, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Microfluidic-assisted metal nanoparticle synthesis: emerging trends toward optical sensing applications.RSC advances · 2026Review
- Surface-enhanced Raman spectroscopy combined microfluidic analytical devices for on-site food safety analysis.Mikrochimica acta · 2026Review
- Chiral Plasmonic Surface Temperature Switching by Several Tens of Kelvins in Titanium Nitride Nanostructures.Nano letters · 2026Article
- Substrate Flexibility and Metal Deposition Method Effects on Piezoelectric-Enhanced SERS in Metal-ZnO Nanorod Nanocomposites.Materials (Basel, Switzerland) · 2025Article
- Controllable Fabrication of ZnO Nanorod Arrays on the Surface of Titanium Material and Their Antibacterial and Anti-Adhesion Properties.Materials (Basel, Switzerland) · 2025Article
- Ultraminiaturized Microfluidic Electrochemical Surface-Enhanced Raman Scattering Chip for Analysis of Neurotransmitters Fabricated by Ship-in-a-Bottle Integration.Small science · 2023Article
- Traditional vs. Microfluidic Synthesis of ZnO Nanoparticles.International journal of molecular sciences · 2023Review
- Acoustofluidic multimodal diagnostic system for Alzheimer's disease.Biosensors & bioelectronics · 2022Article
- Laser Printing of Multilayered Alternately Conducting and Insulating Microstructures.ACS applied materials & interfaces · 2021Article
- Economic Friendly ZnO-Based UV Sensors Using Hydrothermal Growth: A Review.Materials (Basel, Switzerland) · 2021Review
- Silver nanoparticle on zinc oxide array for label-free detection of opioids through surface-enhanced raman spectroscopy.RSC advances · 2021Article
- Ag-ZnO Nanocomposites Are Used for SERS Substrates and Promote the Coupling Reaction of PATP.Materials (Basel, Switzerland) · 2021Article
- Optimization of electron beam-deposited silver nanoparticles on zinc oxide for maximally surface enhanced Raman spectroscopy.Nanoscale advances · 2021Article
- Acoustofluidics-Assisted Fluorescence-SERS Bimodal Biosensors.Small (Weinheim an der Bergstrasse, Germany) · 2020Article
- Remarkable SERS Detection by Hybrid CuACS omega · 2020Article
- SERS Barcode Libraries: A Microfluidic Approach.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2020Article
- Acoustofluidics-Assisted Engineering of Multifunctional Three-Dimensional Zinc Oxide Nanoarrays.ACS nano · 2020Article
- Facile In Situ Photochemical Synthesis of Silver Nanoaggregates for Surface-Enhanced Raman Scattering Applications.Nanomaterials (Basel, Switzerland) · 2020Article
- Microfluidics for ZnO micro-/nanomaterials development: rational design, controllable synthesis, and on-chip bioapplications.Biomaterials science · 2020Review
- Controlling the Morphologies of Silver Aggregates by Laser-Induced Synthesis for Optimal SERS Detection.Nanomaterials (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
In this work, we develop an in situ method to grow highly controllable, sensitive, three-dimensional (3D) surface-enhanced Raman scattering (SERS) substrates via an optothermal effect within microfluidic devices. Implementing this approach, we fabricate SERS substrates composed of Ag@ZnO structures at prescribed locations inside microfluidic channels, sites within which current fabrication of SERS structures has been arduous. Conveniently, properties of the 3D Ag@ZnO nanostructures such as length, packing density, and coverage can also be adjusted by tuning laser irradiation parameters. After exploring the fabrication of the 3D nanostructures, we demonstrate a SERS enhancement factor of up to ∼2×10(6) and investigate the optical properties of the 3D Ag@ZnO structures through finite-difference time-domain simulations. To illustrate the potential value of our technique, low concentrations of biomolecules in the liquid state are detected. Moreover, an integrated cell-trapping function of the 3D Ag@ZnO structures records the surface chemical fingerprint of a living cell. Overall, our optothermal-effect-based fabrication technique offers an effective combination of microfluidics with SERS, resolving problems associated with the fabrication of SERS substrates in microfluidic channels. With its advantages in functionality, simplicity, and sensitivity, the microfluidic-SERS platform presented should be valuable in many biological, biochemical, and biomedical applications.
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